Real-Time, In Vivo Molecular Monitoring Using Electrochemical Aptamer Based Sensors: Opportunities and Challenges

AM Downs, KW Plaxco - ACS sensors, 2022 - ACS Publications
The continuous, real-time measurement of specific molecules in situ in the body would
greatly improve our ability to understand, diagnose, and treat disease. The vast majority of …

From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors

N Arroyo-Currás, P Dauphin-Ducharme, K Scida… - Analytical …, 2020 - pubs.rsc.org
The ultimate goal of implantable bioanalytical sensors is to enable the continuous and
precise monitoring of clinically and physiologically important targets in the body for …

Elucidating the mechanisms underlying the signal drift of electrochemical aptamer-based sensors in whole blood

KK Leung, AM Downs, G Ortega, M Kurnik… - ACS …, 2021 - ACS Publications
The ability to monitor drugs, metabolites, hormones, and other biomarkers in situ in the body
would greatly advance both clinical practice and biomedical research. To this end, we are …

Calibration-free electrochemical biosensors supporting accurate molecular measurements directly in undiluted whole blood

H Li, P Dauphin-Ducharme, G Ortega… - Journal of the …, 2017 - ACS Publications
The need to calibrate to correct for sensor-to-sensor fabrication variation and sensor drift has
proven a significant hurdle in the widespread use of biosensors. To maintain clinically …

Real-time measurement of small molecules directly in awake, ambulatory animals

N Arroyo-Currás, J Somerson… - Proceedings of the …, 2017 - National Acad Sciences
The development of a technology capable of tracking the levels of drugs, metabolites, and
biomarkers in the body continuously and in real time would advance our understanding of …

Calibration-free, seconds-resolved in vivo molecular measurements using fourier-transform impedance spectroscopy interrogation of electrochemical aptamer sensors

B Roehrich, KK Leung, J Gerson, TE Kippin… - ACS …, 2023 - ACS Publications
Electrochemical aptamer-based (EAB) sensors are capable of measuring the concentrations
of specific molecules in vivo, in real time, and with a few-second time resolution. For their …

Dual-reporter drift correction to enhance the performance of electrochemical aptamer-based sensors in whole blood

H Li, N Arroyo-Currás, D Kang, F Ricci… - Journal of the …, 2016 - ACS Publications
The continuous, real-time monitoring of specific molecular targets in unprocessed clinical
samples would enable many transformative medical applications. Electrochemical aptamer …

Finding the lost dissociation constant of electrochemical aptamer-based biosensors

E Rahbarimehr, HP Chao, ZR Churcher… - Analytical …, 2023 - ACS Publications
Electrochemical aptamer-based (E-AB) biosensors afford real-time measurements of the
concentrations of molecules directly in complex matrices and in the body, offering alternative …

Aptamer-based assay of biomolecules: Recent advances in electro-analytical approach

M Hasanzadeh, N Shadjou, M de la Guardia - TrAC Trends in Analytical …, 2017 - Elsevier
Electrochemical aptasensors, which are based on the specificity of aptamer-target
recognition, with electrochemical transduction for analytical purposes have received …

Subsecond-resolved molecular measurements in the living body using chronoamperometrically interrogated aptamer-based sensors

N Arroyo-Currás, P Dauphin-Ducharme, G Ortega… - ACS …, 2018 - ACS Publications
Electrochemical, aptamer-based (E-AB) sensors support the continuous, real-time
measurement of specific small molecules directly in situ in the living body over the course of …