Microstructural and functional gradients are increasingly dissociated in transmodal cortices

C Paquola, R Vos De Wael, K Wagstyl… - PLoS …, 2019 - journals.plos.org
While the role of cortical microstructure in organising neural function is well established, it
remains unclear how structural constraints can give rise to more flexible elements of …

Structural connectivity gradients of the temporal lobe serve as multiscale axes of brain organization and cortical evolution

R Vos de Wael, J Royer, S Tavakol, Y Wang… - Cerebral …, 2021 - academic.oup.com
The temporal lobe is implicated in higher cognitive processes and is one of the regions that
underwent substantial reorganization during primate evolution. Its functions are instantiated …

The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity

A Saberi, C Paquola, K Wagstyl, MD Hettwer… - PLoS …, 2023 - journals.plos.org
The human isocortex consists of tangentially organized layers with unique cytoarchitectural
properties. These layers show spatial variations in thickness and cytoarchitecture across the …

BigBrain 3D atlas of cortical layers: Cortical and laminar thickness gradients diverge in sensory and motor cortices

K Wagstyl, S Larocque, G Cucurull, C Lepage… - PLoS …, 2020 - journals.plos.org
Histological atlases of the cerebral cortex, such as those made famous by Brodmann and
von Economo, are invaluable for understanding human brain microstructure and its …

Multimodal gradients across mouse cortex

BD Fulcher, JD Murray, V Zerbi… - Proceedings of the …, 2019 - National Acad Sciences
The primate cerebral cortex displays a hierarchy that extends from primary sensorimotor to
association areas, supporting increasingly integrated function underpinned by a gradient of …

[HTML][HTML] Gradients in brain organization

BC Bernhardt, J Smallwood, S Keilholz, DS Margulies - NeuroImage, 2022 - Elsevier
Complementary to the progress that has been made in the identification and mapping of
discrete brain areas (Amunts et al., 2020; Genon et al., 2021) and macroscopic functional …

BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets

R Vos de Wael, O Benkarim, C Paquola… - Communications …, 2020 - nature.com
Understanding how cognitive functions emerge from brain structure depends on quantifying
how discrete regions are integrated within the broader cortical landscape. Recent work …

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

JB Burt, M Demirtaş, WJ Eckner, NM Navejar, JL Ji… - Nature …, 2018 - nature.com
Hierarchy provides a unifying principle for the macroscale organization of anatomical and
functional properties across primate cortex, yet microscale bases of specialization across …

Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

B Park, V Kebets, S Larivière, MD Hettwer… - Communications …, 2022 - nature.com
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …

Shifting gradients of macroscale cortical organization mark the transition from childhood to adolescence

HM Dong, DS Margulies, XN Zuo… - Proceedings of the …, 2021 - National Acad Sciences
The transition from childhood to adolescence is marked by pronounced shifts in brain
structure and function that coincide with the development of physical, cognitive, and social …