Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …

Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of
cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells …

The development of metastases is the major cause of death for cancer patients, however,
the mechanisms of tumor invasion and acquisition of capability to metastasize remain …

Cell migration and invasion are critical parameters in the metastatic dissemination of cancer
cells and the formation of metastasis, the major cause of death in cancer patients. Migratory …

Objective The mechanisms of cancer metastasis have been intensely studied recently and
may provide vital therapeutic targets for metastasis prevention. We sought to review the …

Every year about 500,000 people in the United States die as a result of cancer. Among them,
90% exhibit systemic disease with metastasis. Considering this high rate of incidence and …

Metastasis is a complex, multistep biological process, involving a multitude of genes and
biomolecules. Despite the successful therapeutic management of breast cancer, including …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

During tissue invasion individual tumor cells exhibit two interconvertible migration modes,
namely mesenchymal and amoeboid migration. The cellular microenvironment triggers the …

Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …