Earlier age at type 2 diabetes diagnosis is associated with increased genetic risk of cardiovascular disease

H Lee, J Choi, NY Kim, JI Kim, MK Moon, S Lee… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We investigated genetic risk of cardiovascular disease (CVD) by age at type 2
diabetes (T2D) diagnosis. RESEARCH DESIGN AND METHODS We compared incident …

Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study

JS Yun, SH Jung, M Shivakumar, B Xiao… - Cardiovascular …, 2022 - Springer
Background Few studies have examined associations between genetic risk for type 2
diabetes (T2D), lifestyle, clinical risk factors, and cardiovascular disease (CVD). We aimed to …

Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

K Wang, M Kavousi, T Voortman… - European Journal of …, 2021 - academic.oup.com
Aims Data on the lifetime risk of type 2 diabetes (T2D) incidence across different
cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a …

Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes

Q Qi, JB Meigs, KM Rexrode, FB Hu, L Qi - Diabetes care, 2013 - Am Diabetes Assoc
OBJECTIVE To examine the association between genetic predisposition to type 2 diabetes
(T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH …

Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study

LM Raffield, AJ Cox, JJ Carr, BI Freedman, PJ Hicks… - Acta …, 2015 - Springer
Aims It remains unclear whether the high cardiovascular disease (CVD) burden in people
with type 2 diabetes (T2D) is associated with genetic variants that contribute to CVD in …

Causal associations between age at diagnosis of diabetes and cardiovascular outcomes: a Mendelian randomization study

C Ye, L Kong, Y Wang, H Lin, S Wang… - The Journal of …, 2023 - academic.oup.com
Context Whether diabetes diagnosed at different age groups is causally associated with
cardiovascular diseases (CVDs) is unknown. Objective We conducted 2-sample Mendelian …

Genetic risk factors for CVD in type 1 diabetes: the DCCT/EDIC study

I Bebu, S Keshavarzi, X Gao, BH Braffett… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE The role of genetic factors in the risk of cardiovascular disease (CVD) for
patients with type 1 diabetes (T1D) remains unknown. We therefore examined whether …

Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study

JN Adams, LM Raffield, BI Freedman… - Cardiovascular …, 2014 - Springer
Background Type 2 diabetes mellitus (T2DM) is a major cardiovascular disease (CVD) risk
factor. Identification of genetic risk factors for CVD is important to understand disease risk …

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

H Jansen, C Loley, W Lieb, MJ Pencina, CP Nelson… - Atherosclerosis, 2015 - Elsevier
Background The mechanisms underlying the association between diabetes and coronary
artery disease (CAD) risk are unclear. We aimed to assess this association by studying …

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms

JM de Miguel-Yanes, P Shrader, MJ Pencina… - Diabetes …, 2011 - Am Diabetes Assoc
OBJECTIVE To test if knowledge of type 2 diabetes genetic variants improves disease
prediction. RESEARCH DESIGN AND METHODS We tested 40 single nucleotide …