Aging can lead to various disorders in organisms and with the escalating impact of
population aging, the incidence of age-related diseases is steadily increasing. As a major …

Ectopic mineralization-inappropriate biomineralization in soft tissues-is a frequent finding in
physiological aging processes and several common disorders, which can be associated …

The complexities and heterogeneity of the ageing process have slowed the development of
consensus on appropriate biomarkers of healthy ageing. The Medical Research Council …

Extracellular matrix mineralization is an essential physiologic process in the skeleto-dental
tissues. On the other hand,“soft” tissue mineralization (ectopic calcification), associated with …

The complexities and heterogeneity of the ageing process have slowed the development of
consensus on appropriate biomarkers of healthy ageing. The MRC-Arthritis Research UK …

The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Advanced glycation end-products (AGEs) deteriorate bone strength. Among over 40 species
identified in vivo, AGEs other than pentosidine were roughly estimated as total fluorescent …

Specific hallmarks are thought to underlie the ageing process and age-related functional
decline. In this viewpoint, we put forward the hypothesis that disturbances in the process of …

Abstract Changes in bone architecture and metabolism with aging increase the likelihood of
osteoporosis and fracture. Age‐onset osteoporosis is multifactorial, with contributory …

Biomineralization is a multifactorial and complex process, which results in the deposition of
mineral crystals in the extracellular matrix of various tissues. Physiological mineralization is …