Guided by the pharmacophoric features of both EGFR and VEGFR-2 antagonists, two novel
series of 4-methoxyphenyl pyrazole and pyrimidine derivatives [(4a-c) and (5a-c, 6, 7a-c, 8 …

In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …

Fourteen recent thiazolidine-2, 4-diones bearing furan and/or thiophene heterocyclic rings
have been designed, synthesized and assessed for their anticancer activities against four …

Abstract Seventeen new pyrazolo [3, 4-d] pyrimidine derivatives have been designed,
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …

EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very
important in tumor development as well as in angiogenesis and metastasis. In this work, 6 …

A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …

Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …

As dual EGFR and VEGFR‐2 inhibitors, 22 innovative thiazolidine‐2, 4‐diones were
modeled, constructed, and measured for their anticancer performance versus four human …

A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …

Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth
and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the …