[HTML][HTML] Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition

P Pi, Z Zeng, L Zeng, B Han, X Bai, S Xu - Frontiers in Pharmacology, 2023 - frontiersin.org
As the outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) first broke out in Hubei Province, China, at the end of 2019. It has brought …

Pulmonary fibrosis in COVID-19: mechanisms, consequences and targets

S O'Reilly - QJM: An International Journal of Medicine, 2023 - academic.oup.com
Pulmonary fibrosis is characterized by extracellular deposition in the lung primarily collagen
but also other ECM molecules. The primary cell type responsible for this is the myofibroblast …

Cytokines as drivers: Unraveling the mechanisms of epithelial-mesenchymal transition in COVID-19 lung fibrosis

L Zhang, X Zhang, X Deng, P Wang, Y Mo… - Biochemical and …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other viruses, can
induce proliferation of myofibroblasts and even lead to fibrosis in the lung. Epithelial …

[HTML][HTML] Common molecular pathways between post-COVID19 syndrome and lung fibrosis: a scoping review

L Bergantini, A Mainardi, M d'Alessandro… - Frontiers in …, 2022 - frontiersin.org
The pathogenetic mechanism of post-Covid-19 pulmonary fibrosis is currently a topic of
intense research interest, but still largely unexplored. The aim of this work was to carry out a …

The role of cytokines and Molecular pathways in Lung Fibrosis following SARS-CoV-2 infection: a physiopathologic (re) view

M Lazar, M Sandulescu, EC Barbu, CE Chitu-Tisu… - Biomedicines, 2024 - mdpi.com
SARS-CoV-2 infection is a significant health concern that needs to be addressed not only
during the initial phase of infection but also after hospitalization. This is the consequence of …

[HTML][HTML] COVID-19: immunohistochemical analysis of TGF-β signaling pathways in pulmonary fibrosis

CB Vaz de Paula, S Nagashima, V Liberalesso… - International journal of …, 2021 - mdpi.com
Acute respiratory distress syndrome (ARDS) followed by repair with lung remodeling is
observed in COVID-19. These findings can lead to pulmonary terminal fibrosis, a form of …

Potential mechanisms for lung fibrosis associated with COVID-19 infection

T Parimon, M Espindola, A Marchevsky… - … Journal of Medicine, 2023 - academic.oup.com
Pulmonary fibrosis is a sequelae of Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) infection that currently lacks effective preventative or therapeutic measures …

[HTML][HTML] Pathophysiology of pulmonary fibrosis in the context of COVID-19 and implications for treatment: A narrative review

S Tran, A Ksajikian, J Overbey, P Li, Y Li - Cells, 2022 - mdpi.com
Pulmonary fibrosis (PF) is a feared outcome of many pulmonary diseases which results in a
reduction in lung compliance and capacity. The development of PF is relatively rare, but it …

[HTML][HTML] From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

JE Michalski, JS Kurche, DA Schwartz - Translational Research, 2022 - Elsevier
While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

“A chain only as strong as its weakest link”: an up-to-date literature review on the bidirectional interaction of pulmonary fibrosis and COVID-19

R Crisan-Dabija, CA Pavel, IV Popa… - Journal of proteome …, 2020 - ACS Publications
The COVID-19 pandemic rapidly became a worldwide healthcare emergency affecting
millions of people, with poor outcomes for patients with chronic conditions and enormous …