Hepatic stellate cells (HSC) are the source of extracellular matrix (ECM) whose
overproduction leads to fibrosis, a condition that impairs liver functions in chronic liver …

Background Recent results from single cell gene and protein regulation studies are starting
to uncover the previously underappreciated fact that individual cells within a population …

Hepatic fibrosis is a key feature of progressive liver disease and an important therapeutic
target. Hepatic stellate cells (HSCs) are activated by damage-related stimuli, which promote …

Activation and deactivation of hepatic stellate cells (HSCs) is an important mechanism
contributing to both healthy liver function and development of liver diseases, which relies on …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver
fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently …

Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects
millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis …

Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic
steatohepatitis which is undergoing a dramatic evolution given the obesity progression …

Liver fibrosis is a severe health problem worldwide with increasing incidence. However,
specific drugs for treatment of hepatic fibrosis are currently not available. Accordingly, there …

New research published in Nature Communications has confirmed hepatic stellate cells
(HSCs) as key contributors towards liver fibrosis in vivo irrespective of the underlying …