Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …

Transcriptome analysis enables the study of gene expression in human tissues and is a
valuable tool to characterise liver function and gene expression dynamics during liver …

The critical functions of the human liver are coordinated through the interactions of hepatic
parenchymal and non‐parenchymal cells. Recent advances in single‐cell transcriptional …

The hepatic mesenchyme has been studied extensively in the context of liver fibrosis;
however, much less is known regarding the role of mesenchymal cells during liver …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

Background & Aims The multiple vital functions of the human liver are performed by highly
specialised parenchymal and non-parenchymal cells organised in complex collaborative …

The incidence of liver disease is increasing globally. The only curative therapy for severe
end-stage liver disease, liver transplantation, is limited by the shortage of organ donors. In …

Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the
lack of detailed knowledge about specific cellular contributors mediating fibrogenesis …

The liver is unique in its ability to regenerate from a wide range of injuries and diseases.
Liver regeneration centers around hepatocyte proliferation and requires the coordinated …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …