G Protein-Coupled Receptors and Ion Channels Involvement in Cisplatin-Induced Peripheral Neuropathy: A Review of Preclinical Studies

G Becker, SF Atuati, SM Oliveira - Cancers, 2024 - mdpi.com
Simple Summary Cisplatin is a chemotherapy drug extensively used to treat cancer,
improving the survival of cancer patients. Although effective for this purpose, its use is …

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity

SW Hohmann, C Angioni, S Tunaru, S Lee, CJ Woolf… - Scientific Reports, 2017 - nature.com
Chemotherapy-induced peripheral neuropathic pain (CIPN) is a common and severe
debilitating side effect of many widely used cytostatics. However, there is no approved …

Emerging trends in understanding chemotherapy-induced peripheral neuropathy

J Ferrier, V Pereira, J Busserolles, N Authier… - Current pain and …, 2013 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) is a major concern in oncology
practice given the increasing number of cancer survivors and the lack of effective treatment …

Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

VA Carozzi, A Canta, A Chiorazzi - Neuroscience letters, 2015 - Elsevier
Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Therapeutic agents for oxaliplatin-induced peripheral neuropathy; experimental and clinical evidence

T Kawashiri, K Mine, D Kobayashi, M Inoue… - International journal of …, 2021 - mdpi.com
Oxaliplatin is an essential drug in the chemotherapy of colorectal, gastric, and pancreatic
cancers, but it frequently causes peripheral neuropathy as a dose-limiting factor. So far …

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin

JR Deuis, YL Lim, S Rodrigues de Sousa… - Neuro …, 2014 - academic.oup.com
Background Peripheral neuropathy is the major dose-limiting side effect of cisplatin and
oxaliplatin, and there are currently no effective treatments available. The aim of this study …

Chemotherapy-induced peripheral neuropathy

JC Fehrenbacher - Progress in molecular biology and translational …, 2015 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is common in patients receiving
anticancer treatment and can affect survivability and long-term quality of life of the patient …

Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment

J Burgess, M Ferdousi, D Gosal, C Boon… - Oncology and …, 2021 - Springer
Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

[HTML][HTML] Probing the peripheral immune response in mouse models of oxaliplatin-induced peripheral neuropathy highlights their limited translatability

ZL Hore, S Villa-Hernandez, F Denk - Wellcome Open Research, 2021 - ncbi.nlm.nih.gov
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect
of various chemotherapeutic agents, including oxaliplatin. It is highly prevalent amongst …

Chemotherapy‐induced peripheral neuropathy: a current review

NP Staff, A Grisold, W Grisold… - Annals of …, 2017 - Wiley Online Library
Chemotherapy‐induced peripheral neuropathy (CIPN) is a common dose‐limiting side effect
experienced by patients receiving treatment for cancer. Approximately 30 to 40% of patients …