Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Protein modifications are biologically important events that may be studied by mass
spectrometry‐based high‐throughput proteome analyses. In recent years, several new …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Introduction: Acetylation is a widely occurring post-translational modification (PTM) of
proteins that plays a crucial role in many cellular physiological and pathological processes …

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

For the first 30 years since its discovery, reversible protein acetylation has been studied and
understood almost exclusively in the context of histone modification and gene transcription …

Post‐translational modification of proteins is ubiquitous and mediates many cellular
processes, including intracellular localization, protein–protein interactions, enzyme activity …

Lysine acetylation is a post-translational modification that critically regulates gene
transcription by targeting histones as well as a variety of transcription factors in the nucleus …

Protein acetylation plays a critical regulatory role in eukaryotes but until recently its
significance and function in bacteria and the archaea were obscure. It is now clear, however …