Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study
C Peng, P Lei, X Li, H Xie, X Yang, T Zhang… - Lipids in Health and …, 2019 - Springer
Background Sterol regulatory-element binding proteins (SREBPs) and mir-33 (miR-33a, miR-
33b), which are encoded by the introns of SREBPs, are key factors in the lipid metabolism …
33b), which are encoded by the introns of SREBPs, are key factors in the lipid metabolism …
SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo
T Nishino, T Horie, O Baba, N Sowa… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Atherosclerosis is a common disease caused by a variety of metabolic and
inflammatory disturbances. MicroRNA (miR)-33a within SREBF2 (sterol regulatory element …
inflammatory disturbances. MicroRNA (miR)-33a within SREBF2 (sterol regulatory element …
Characterization of polymorphic structure of SREBP-2 gene: role in atherosclerosis
Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription
factors that control the metabolism of cholesterol and fatty acids in mammalian cells. We …
factors that control the metabolism of cholesterol and fatty acids in mammalian cells. We …
A new DNA polymorphism in the 5′ untranslated region of the human SREBP-1a is related to development of atherosclerosis in high cardiovascular risk population
B Védie, X Jeunemaitre, JL Mégnien, V Atger, A Simon… - Atherosclerosis, 2001 - Elsevier
Sterol-regulatory element binding proteins (SREBPs) are ubiquitous transcription factors that
regulate the genes encoding key proteins in the control of cholesterol homeostasis. We …
regulate the genes encoding key proteins in the control of cholesterol homeostasis. We …
Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
M Yang, W Liu, C Pellicane, C Sahyoun… - Journal of lipid …, 2014 - ASBMB
Dysregulation of cholesterol homeostasis is associated with various metabolic diseases,
including atherosclerosis and type 2 diabetes. The sterol response element binding protein …
including atherosclerosis and type 2 diabetes. The sterol response element binding protein …
[HTML][HTML] The elevation of miR-185-5p alleviates high-fat diet-induced atherosclerosis and lipid accumulation in vivo and in vitro via SREBP2 activation
W Tan, G Wang, G Liu, D You, M Wei, X Jin… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Objective: SREBP2, a member of the SREBP family, is a primary regulator of lipid
metabolism. In recent years, an increasing number of studies have suggested that miRNAs …
metabolism. In recent years, an increasing number of studies have suggested that miRNAs …
Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis
R Gopoju, S Panangipalli, S Kotamraju - Free Radical Biology and …, 2018 - Elsevier
Lipids are responsible for the atheromatous plaque formation during atherosclerosis by their
deposition in the subendothelial intima of the aorta, leading to infarction. Sterol regulatory …
deposition in the subendothelial intima of the aorta, leading to infarction. Sterol regulatory …
Identification of novel genes and pathways regulating SREBP transcriptional activity
S Chatterjee, JD Szustakowski, NR Nanguneri… - Plos one, 2009 - journals.plos.org
Background Lipid metabolism in mammals is orchestrated by a family of transcription factors
called sterol regulatory element-binding proteins (SREBPs) that control the expression of …
called sterol regulatory element-binding proteins (SREBPs) that control the expression of …
Macrophage SR-B1 in atherosclerotic cardiovascular disease
T Huby, W Le Goff - Current Opinion in Lipidology, 2022 - journals.lww.com
These studies shed new light on the atheroprotective role of SR-B1 by emphasizing its
essential contribution in macrophages during atherogenesis as a function of lesion stages …
essential contribution in macrophages during atherogenesis as a function of lesion stages …
miR-33 links SREBP-2 induction to repression of sterol transporters
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR)
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …