The “normal” immune response to an insult triggers a highly regulated response determined
by the interaction of various immunocompetent cells with pro-and anti-inflammatory …

A dysregulated host response is a common feature in critically ill patients due to both
infectious and non-infectious origins that can lead to life-threatening organ dysfunction …

Cytokines play a critical role in coordinating and amplifying a host immune response to
infection. The normal pattern of localized and systemic release of proinflammatory and anti …

Multiple organ failure following a septic event derives from immune dysregulation. Many of
the mediators of this process are humoral factors (cytokines), which could theoretically be …

BACKGROUND Sepsis is a severe clinical syndrome related to the host response to
infection. The severity of infections is due to an activation cascade that will lead to an auto …

Introduction: Sepsis results in immunologic disturbances with the release of various
inflammatory mediators such as cytokines. Cytokines can damage the cells, and the …

Introduction Hemoadsorption using CytoSorb has gained attention as a potential
immunotherapy to control systemic inflammation and sepsis. We report on a patient with …

Sepsis is a well-recognized healthcare issue worldwide, ultimately resulting in significant
mortality, morbidity and resource utilization during and after critical illness. In its most severe …

BACKGROUND Cytokines and inflammatory mediators are the hallmarks of sepsis.
Extracorporeal cytokine hemoadsorption devices are the newer clinical support system to …

Although improving, the mortality from septic shock still remains high despite increased
international awareness. As a consequence, much effort has focused on alternative …