The olfactory G protein-coupled receptor (Olfr-78/OR51E2) modulates the intestinal response to colitis

K Kotlo, AN Anbazhagan… - … of Physiology-Cell …, 2020 - journals.physiology.org
Olfactory receptor-78 (Olfr-78) is a recently identified G protein-coupled receptor activated by
short-chain fatty acids acetate and propionate. A suggested role for this receptor exists in the …

Olfactory receptors in macrophages and inflammation

M Orecchioni, H Matsunami, K Ley - Frontiers in immunology, 2022 - frontiersin.org
Olfactory receptors (ORs) that bind odorous ligands are the largest family of G-protein-
coupled receptors. In the olfactory epithelium, approximately 400 and 1,100 members are …

The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages

SMP Vadevoo, GR Gunassekaran… - Proceedings of the …, 2021 - National Acad Sciences
Expression and function of odorant receptors (ORs), which account for more than 50% of G
protein–coupled receptors, are being increasingly reported in nonolfactory sites. However …

Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon

J Fleischer, R Bumbalo, V Bautze, J Strotmann… - Cell and Tissue …, 2015 - Springer
The precise regulation of digestive and other physiological processes in the gastrointestinal
tract in accordance with the food ingested requires continuous monitoring of the luminal …

Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis

L Weber, K Al-Refae, J Ebbert, P Jägers, J Altmüller… - PloS one, 2017 - journals.plos.org
The analysis and functional characterization of ectopically expressed human olfactory
receptors (ORs) is becoming increasingly important, as many ORs have been identified in …

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

JL Pluznick, RJ Protzko, H Gevorgyan… - Proceedings of the …, 2013 - National Acad Sciences
Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation
and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor …

Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice

A Nakashima, N Nakashima, K Nakashima, M Takano - Molecular Brain, 2022 - Springer
Olfactory receptors have been detected in extraolfactory organs. Olfactory receptor 78
(Olfr78), proposed to respond to small organic acids, is widely expressed in the kidney …

Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding …

P Mermer, J Strotmann, W Kummer… - Histochemistry and Cell …, 2021 - Springer
The olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) is a
member of the G protein-coupled receptor family mediating olfactory chemosensation, but it …

Olfactory receptor 43 reduces hepatic lipid accumulation and adiposity in mice

C Wu, TT Thach, YJ Kim, SJ Lee - … et Biophysica Acta (BBA)-Molecular and …, 2019 - Elsevier
Olfactory receptors are primarily expressed in nasal olfactory epithelium, but these receptors
are also ectopically expressed in diverse tissues. In this study, we investigated the biological …

Characterizing novel olfactory receptors expressed in the murine renal cortex

VL Halperin Kuhns, J Sanchez… - American Journal …, 2019 - journals.physiology.org
The kidney uses specialized G protein-coupled receptors, including olfactory receptors
(ORs), to act as sensors of molecules and metabolites. In the present study, we cloned and …