Whole Slide Images (WSIs) provide exceptional detail for studying tissue architecture at the
cell level. To study tumour microenvironment (TME) with the context of various protein …

Spatial analyses can reveal important interactions between and among cells and their
microenvironment. However, most existing staining methods are limited to a handful of …

Image registration involves finding the best alignment between different images of the same
object. In these tasks, the object in question is viewed differently in each of the images (eg …

Joint analysis of multiple protein expressions and tissue morphology patterns is important for
disease diagnosis, treatment planning, and drug development, requiring cross-staining …

Joint analysis of multiple biomarker images and tissue morphology is important for disease
diagnosis, treatment planning and drug development. It requires cross-staining comparison …

Consecutive thin sections of tissue samples make it possible to study local variation in eg
protein expression and tumor heterogeneity by staining for a new protein in each section. In …

For many disease conditions, tissue samples are colored with multiple dyes and stains to
add contrast and location information for specific proteins to accurately identify and …

Interest in spatial omics is on the rise, but generation of highly multiplexed images remains
challenging, due to cost, expertise, methodical constraints, and access to technology. An …

Background High resolution 2D whole slide imaging provides rich information about the
tissue structure. This information can be a lot richer if these 2D images can be stacked into a …

Three-dimensional (3D) digital pathology has been emerging for next-generation tissue
based cancer research. To enable such histopathology image volume analysis, serial …