The role of metabolic plasticity of tumor-associated macrophages in shaping the tumor microenvironment immunity

MN Hasan, O Capuk, SM Patel, D Sun - Cancers, 2022 - mdpi.com
Simple Summary Tumor associated macrophages (TAMs) support disease progression by
providing tumor cells cytokines and chemokines necessary for malignant growth and …

Tumor-associated macrophages: new insights on their metabolic regulation and their influence in cancer immunotherapy

L Xiao, Q Wang, H Peng - Frontiers in Immunology, 2023 - frontiersin.org
Tumor-associated macrophages (TAMs) are a dynamic and heterogeneous cell population
of the tumor microenvironment (TME) that plays an essential role in tumor formation and …

Leveraging macrophage metabolism for anticancer therapy: opportunities and pitfalls

P Saha, P Ettel, T Weichhart - Trends in Pharmacological Sciences, 2024 - cell.com
Tumor-associated macrophages (TAMs) constitute an important part of the tumor
microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia …

Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities

Y Qian, Y Yin, X Zheng, Z Liu, X Wang - Biomarker Research, 2024 - Springer
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse
functions in tumors. Their identity is determined not only by intrinsic factors, such as origins …

The Metabolic Features of Tumor‐Associated Macrophages: Opportunities for Immunotherapy?

SS Mojsilovic, S Mojsilovic, VH Villar… - Analytical Cellular …, 2021 - Wiley Online Library
Besides transformed cells, the tumors are composed of various cell types that contribute to
undesirable tumor progression. Tumor‐associated macrophages (TAMs) are the most …

Cellular metabolism of tumor‐associated macrophages–functional impact and consequences

K Rabold, MG Netea, GJ Adema… - FEBS letters, 2017 - Wiley Online Library
Macrophages are innate immune cells that play a role not only in host defense against
infections, but also in the pathophysiology of autoimmune and autoinflammatory disorders …

[HTML][HTML] The role of metabolic reprogramming of tumor-associated macrophages in shaping the immunosuppressive tumor microenvironment

L Li, Y Tian - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Macrophages are potent immune effector cells in innate immunity and exert dual-effects in
the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) make up a …

Macrophages and metabolism in the tumor microenvironment

I Vitale, G Manic, LM Coussens, G Kroemer, L Galluzzi - Cell metabolism, 2019 - cell.com
Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

[HTML][HTML] Metabolic reprograming of tumor-associated macrophages

A Puthenveetil, S Dubey - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
A large body of scientific evidence corroborated by clinical and animal model experiments
indicates that tumor-associated macrophages (TAMs) play a crucial role in tumor …

[HTML][HTML] Metabolic programming of tumor associated macrophages in the context of cancer treatment

T Crezee, K Rabold, L de Jong, M Jaeger… - Annals of …, 2020 - ncbi.nlm.nih.gov
Tumor associated macrophages (TAMs) are important components of the tumor
microenvironment (TME). They are characterized by a remarkable functional plasticity …