We integrated genomic and bioinformatic analyses, using data from the largest genome-
wide association study of cocaine dependence (CD; n= 6546; 82.37% with CD; 57.39 …

We investigated the genetic and molecular architecture of cocaine dependence (CD) and
cocaine use by integrating genome‐/transcriptome‐wide analyses. To prioritize candidates …

Background: Phenotypic heterogeneity and complicated gene–environment interplay in
etiology are among the primary factors that hinder the identification of genetic variants …

Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates
represent a substantial public health crisis that exacts tremendous personal and financial …

Drug addiction, one of the major health problems worldwide, is characterized by the loss of
control in drug intake, craving, and withdrawal. At the individual level, drugs of abuse …

Chronic drug abuse, craving, and relapse are thought to be linked to long-lasting changes in
neural gene expression arising through transcriptional and chromatin-related mechanisms …

Until recently, knowledge of the impact of abused drugs on gene and protein expression in
the brain was limited to less than 100 targets. With the advent of high-throughput genomic …

ABSTRACT Background: Data from the Global Burden of Disease Study 2016 recently
estimated that after opioid and cannabis use disorders, cocaine use disorders were among …

We report a genome-wide association study (GWAS) for cocaine dependence (CD) in three
sets of African-and European-American subjects (AAs and EAs, respectively) to identify …

Decades of research on cocaine has produced volumes of data that have answered many
important questions about the nature of this highly addictive drug. Sadly, none of this …