[HTML][HTML] Graph pangenome captures missing heritability and empowers tomato breeding

Y Zhou, Z Zhang, Z Bao, H Li, Y Lyu, Y Zan, Y Wu… - Nature, 2022 - nature.com
Missing heritability in genome-wide association studies defines a major problem in genetic
analyses of complex biological traits,. The solution to this problem is to identify all causal …

[HTML][HTML] Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

Identifying genetic variants underlying phenotypic variation in plants without complete genomes

Y Voichek, D Weigel - Nature genetics, 2020 - nature.com
Structural variants and presence/absence polymorphisms are common in plant genomes,
yet they are routinely overlooked in genome-wide association studies (GWAS). Here, we …

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines

S Atwell, YS Huang, BJ Vilhjálmsson, G Willems… - Nature, 2010 - nature.com
Although pioneered by human geneticists as a potential solution to the challenging problem
of finding the genetic basis of common human diseases,, genome-wide association (GWA) …

The tomato pan-genome uncovers new genes and a rare allele regulating fruit flavor

L Gao, I Gonda, H Sun, Q Ma, K Bao, DM Tieman… - Nature …, 2019 - nature.com
Modern tomatoes have narrow genetic diversity limiting their improvement potential. We
present a tomato pan-genome constructed using genome sequences of 725 …

[HTML][HTML] Graph-based pan-genome reveals structural and sequence variations related to agronomic traits and domestication in cucumber

H Li, S Wang, S Chai, Z Yang, Q Zhang, H Xin… - Nature …, 2022 - nature.com
Structural variants (SVs) represent a major source of genetic diversity and are related to
numerous agronomic traits and evolutionary events; however, their comprehensive …

[HTML][HTML] Chromosome-scale and haplotype-resolved genome assembly of a tetraploid potato cultivar

H Sun, WB Jiao, K Krause, JA Campoy, M Goel… - Nature …, 2022 - nature.com
Potato is the most widely produced tuber crop worldwide. However, reconstructing the four
haplotypes of its autotetraploid genome remained an unsolved challenge. Here, we report …

Graph-based pan-genomes: increased opportunities in plant genomics

S Wang, YQ Qian, RP Zhao, LL Chen… - Journal of …, 2023 - academic.oup.com
Due to the development of sequencing technology and the great reduction in sequencing
costs, an increasing number of plant genomes have been assembled, and numerous …

The AraGWAS Catalog: a curated and standardized Arabidopsis thaliana GWAS catalog

M Togninalli, Ü Seren, D Meng, J Fitz… - Nucleic acids …, 2018 - academic.oup.com
The abundance of high-quality genotype and phenotype data for the model organism
Arabidopsis thaliana enables scientists to study the genetic architecture of many complex …

Genomic innovation for crop improvement

MW Bevan, C Uauy, BBH Wulff, J Zhou, K Krasileva… - Nature, 2017 - nature.com
Crop production needs to increase to secure future food supplies, while reducing its impact
on ecosystems. Detailed characterization of plant genomes and genetic diversity is crucial …