[HTML][HTML] Commentary Potential Enhancement by 3-Deazauridine of the Antiviral Activity of Molnupiravir in Patients with COVID-19

RL Momparler - Advances in Infectious Diseases, 2023 - scirp.org
Background: Molnupiravir, N4-hydroxycytidine-5'-isopropyl ester, is an oral prodrug of N4-
deoxycytidine (NHC), a nucleoside analog, which has in vitro activity against SARS-CoV-2 …

Role of Molnupiravir in the Treatment of COVID-19

A Sharma, VM Patil, M Dahiya, GP Singh… - Anti-Infective …, 2023 - ingentaconnect.com
Background: Molnupiravir is a ribonucleoside analog and exhibits its antiviral mechanism by
inhibiting replication. Preclinical studies have been reported that support the role of …

[PDF][PDF] SCIENTIFIC TALKS OF PERSPECTIVES FOR SPECIFICITIES OF MOLNUPIRAVIR AND ITS PHARMACOLOGICAL ACTION TO COMBAT COVID-19 VIRUS …

M Beglaryan - researchgate.net
Molnupiravir (EIDD-2801/MK-4482) is a prodrug for the ribonucleoside analogue β-d-N4-
hydroxycytidine (NHC; EIDD-1931), which has been shown to be useful in the treatment of …

[PDF][PDF] Molnupiravir: A Versatile Prodrug against SARS-CoV-2 Variants. Metabolites 2023, 13, 309

D Teli, P Balar, K Patel, A Sharma, V Chavda, L Vora - 2023 - pureadmin.qub.ac.uk
The nucleoside analog β-D-N4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

Molnupiravir: A versatile prodrug against SARS-CoV-2 variants

D Teli, P Balar, K Patel, A Sharma, V Chavda, L Vora - Metabolites, 2023 - mdpi.com
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

Safety and efficacy of molnupiravir in SARS‐CoV‐2‐infected patients: A real‐life experience

A De Vito, A Colpani, A Bitti, B Zauli… - Journal of Medical …, 2022 - Wiley Online Library
Since the start of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
pandemic, several treatments have been proposed to cure coronavirus disease 2019 …

Molnupiravir: an antiviral drug against COVID-19

B Dave, KC Shah, MR Chorawala, N Shah, P Patel… - Archives of …, 2023 - Springer
Abstract SARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths
worldwide and poses significant challenges. Researchers have recently studied a new …

Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences

S Singla, S Goyal - Bulletin of the National Research Centre, 2022 - Springer
Background The study was aimed at encapsulating the evidence of in vitro and in vivo
antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2 …

[PDF][PDF] Pharmacokinetics of ß-d-N4-hydroxycytidine, the active metabolite of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection.

GG Ewings, S Khoo - scholar.archive.org
Background: Molnupiravir, an orally administered prodrug of the broadly active, direct-acting
antiviral, ribonucleoside analogue ß-d-N4-hydroxycytidine (NHC) is a promising COVID-19 …

[PDF][PDF] Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication

KM Stegmann, A Dickmanns, N Heinen, C Blaurock… - Iscience, 2022 - cell.com
The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug
molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 …