Blood-brain barrier-penetrative fluorescent anticancer agents triggering paraptosis and ferroptosis for glioblastoma therapy

J Wang, M Cao, L Han, P Shangguan, Y Liu, Y Zhong… - 2024 - chemrxiv.org
Currently used drugs for glioblastoma (GBM) treatments are ineffective, primarily due to the
significant challenges posed by strong drug resistance, poor blood-brain barrier (BBB) …

Drug Repurposing‐Based Brain‐Targeting Self‐Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma

J Liang, L Li, H Tian, Z Wang, G Liu, X Duan, M Guo… - Small, 2023 - Wiley Online Library
Glioblastoma (GBM), the most aggressive and lethal form of malignant brain tumor, is a
therapeutic challenge due to the drug filtration capabilities of the blood‐brain barrier (BBB) …

Brain‐targeted HFn‐Cu‐rego nanoplatform for site‐specific delivery and manipulation of autophagy and cuproptosis in glioblastoma

W Jia, H Tian, J Jiang, L Zhou, L Li, M Luo, N Ding… - Small, 2023 - Wiley Online Library
Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …

Biomimetic macrophage membrane-camouflaged nanoparticles induce ferroptosis by promoting mitochondrial damage in glioblastoma

Z Cao, X Liu, W Zhang, K Zhang, L Pan, M Zhu, H Qin… - ACS …, 2023 - ACS Publications
The increasing understanding of ferroptosis has indicated its role and therapeutic potential
in cancer; however, this knowledge has yet to be translated into effective therapies …

NIR-promoted ferrous ion regeneration enhances ferroptosis for glioblastoma treatment

K Xue, R Yang, Y An, Y Ding, S Li, F Miao, D Liu… - Journal of Controlled …, 2024 - Elsevier
Ferroptosis, a unique iron-dependent mode of cell death characterized by lipid peroxide
accumulation, holds significant potential for the treatment of glioblastoma (GBM). However …

[HTML][HTML] A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

MA Banu, A Dovas, MG Argenziano, W Zhao… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Glioma cells hijack developmental transcriptional programs to control cell state. During
neural development, lineage trajectories rely on specialized metabolic pathways. However …

A Brain‐Targeting NIR‐II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma

J Zhang, L Han, H Wu, Y Zhong… - Advanced …, 2023 - Wiley Online Library
Abstract Near‐infrared‐II (NIR‐II) ferroptosis activators offer promising potentials in in vivo
theranostics of deep tumors, such as glioma. However, most cases are nonvisual iron …

Adaptive changes allow targeting of ferroptosis for glioma treatment

R Huang, R Dong, N Wang, Y He, P Zhu… - Cellular and Molecular …, 2022 - Springer
Ferroptosis is a type of regulated cell death that plays an essential role in various brain
diseases, including cranial trauma, neuronal diseases, and brain tumors. It has been …

[HTML][HTML] Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment

S Wan, G Zhang, R Liu, MN Abbas, H Cui - Cell Communication and …, 2023 - Springer
Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma
multiforme (GBM) being the most malignant, aggressive, and drug resistant. Most drugs are …

[HTML][HTML] Emerging role of ferroptosis in glioblastoma: Therapeutic opportunities and challenges

S Zhuo, G He, T Chen, X Li, Y Liang, W Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Glioblastoma (GBM) is the most common malignant craniocerebral tumor. The treatment of
this cancer is difficult due to its high heterogeneity and immunosuppressive …