Dissecting the genetics of complex traits using summary association statistics
B Pasaniuc, AL Price - Nature reviews genetics, 2017 - nature.com
During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …
successfully identify tens of thousands of genetic variants associated with complex traits and …
[PDF][PDF] A powerful approach to estimating annotation-stratified genetic covariance via GWAS summary statistics
Despite the success of large-scale genome-wide association studies (GWASs) on complex
traits, our understanding of their genetic architecture is far from complete. Jointly modeling …
traits, our understanding of their genetic architecture is far from complete. Jointly modeling …
[PDF][PDF] Integrating gene expression with summary association statistics to identify genes associated with 30 complex traits
Although genome-wide association studies (GWASs) have identified thousands of risk loci
for many complex traits and diseases, the causal variants and genes at these loci remain …
for many complex traits and diseases, the causal variants and genes at these loci remain …
[PDF][PDF] Contrasting the genetic architecture of 30 complex traits from summary association data
Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …
variants to the heritability of complex traits have yielded important insights into the genetic …
Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
An atlas of genetic associations in UK Biobank
O Canela-Xandri, K Rawlik, A Tenesa - Nature genetics, 2018 - nature.com
Genome-wide association studies (GWAS) have identified many loci contributing to variation
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
in complex traits, yet the majority of loci that contribute to the heritability of complex traits …
Explaining additional genetic variation in complex traits
Genome-wide association studies (GWAS) have provided valuable insights into the genetic
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …
[PDF][PDF] Local genetic correlation gives insights into the shared genetic architecture of complex traits
Although genetic correlations between complex traits provide valuable insights into
epidemiological and etiological studies, a precise quantification of which genomic regions …
epidemiological and etiological studies, a precise quantification of which genomic regions …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
Improved analyses of GWAS summary statistics by reducing data heterogeneity and errors
Abstract Summary statistics from genome-wide association studies (GWAS) have facilitated
the development of various summary data-based methods, which typically require a …
the development of various summary data-based methods, which typically require a …