Optimizing methods to isolate melanopsin-directed responses

S Uprety, AJ Zele, B Feigl, D Cao, P Adhikari - JOSA A, 2021 - opg.optica.org
The intrinsic melanopsin photoresponse may initiate visual signals that differ in
spatiotemporal characteristics from the cone-opsin-and rhodopsin-mediated signals …

[HTML][HTML] Protocol for isolation of melanopsin and rhodopsin in the human eye using silent substitution

TW Nugent, DD Carter, S Uprety, P Adhikari, B Feigl… - STAR protocols, 2023 - Elsevier
Melanopsin-mediated visual and non-visual functions are difficult to study in vivo. To isolate
melanopsin responses, non-standard light stimulation instruments are required, with at least …

[HTML][HTML] Melanopic stimulation does not alter psychophysical threshold sensitivity for luminance flicker

J Vincent, EB Haggerty, DH Brainard, GK Aguirre - Scientific reports, 2021 - nature.com
In addition to the rod and cone photoreceptors the retina contains intrinsically photosensitive
retinal ganglion cells (ipRGCs). These cells express the photopigment melanopsin and are …

[HTML][HTML] Melanopsin photoreception contributes to human visual detection, temporal and colour processing

AJ Zele, B Feigl, P Adhikari, ML Maynard, D Cao - Scientific reports, 2018 - nature.com
The visual consequences of melanopsin photoreception in humans are not well understood.
Here we studied melanopsin photoreception using a technique of photoreceptor silent …

[HTML][HTML] Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision

S Uprety, P Adhikari, B Feigl, AJ Zele - Iscience, 2022 - cell.com
To evaluate the nature of interactions between visual pathways transmitting the slower
melanopsin and faster rod and cone signals, we implement a temporal phase summation …

[HTML][HTML] Light adaptation characteristics of melanopsin

M Pant, AJ Zele, B Feigl, P Adhikari - Vision Research, 2021 - Elsevier
Following photopigment bleaching, the rhodopsin and cone-opsins show a characteristic
exponential regeneration in the dark with a photocycle dependent on the retinal pigment …

Melanopsin-mediated amplification of cone signals in the human visual cortex

P Adhikari, S Uprety, B Feigl… - Proceedings of the …, 2024 - royalsocietypublishing.org
The ambient daylight variation is coded by melanopsin photoreceptors and their luxotonic
activity increases towards midday when colour temperatures are cooler, and irradiances are …

Opponent melanopsin and S-cone signals in the human pupillary light response

M Spitschan, S Jain, DH Brainard… - Proceedings of the …, 2014 - National Acad Sciences
In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically
photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals …

[HTML][HTML] The method of silent substitution for examining melanopsin contributions to pupil control

M Spitschan, T Woelders - Frontiers in Neurology, 2018 - frontiersin.org
The human pupillary light response is driven by all classes of photoreceptors in the human
eye—the three classes of cones, the rods, and the intrinsically photosensitive retinal …

[HTML][HTML] Melanopsin enhances image persistence

T Woelders, AE Allen, RJ Lucas - Current Biology, 2023 - cell.com
Contributions of the inner retinal photopigment melanopsin to human visual perception are
incompletely understood. Here, we use a four-primary display to produce stimuli differing in …