[HTML][HTML] TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration
GP Grolez, DV Gordiendko, M Clarisse… - Cell death & …, 2019 - nature.com
In prostate carcinogenesis, androgens are known to control the expression of the transient
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …
[HTML][HTML] TRPM8 puts the chill on prostate cancer
GP Grolez, D Gkika - Pharmaceuticals, 2016 - mdpi.com
Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …
countries. Several studies suggest that variations in calcium homeostasis are involved in …
[HTML][HTML] Therapeutic potential of TRPM8 antagonists in prostate cancer
M Di Donato, C Ostacolo, P Giovannelli, V Di Sarno… - Scientific reports, 2021 - nature.com
Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate
cancer, although its mechanism of action remains unclear. Here, we have characterized and …
cancer, although its mechanism of action remains unclear. Here, we have characterized and …
[HTML][HTML] Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has
emerged as a promising prognostic marker and putative therapeutic target in prostate …
emerged as a promising prognostic marker and putative therapeutic target in prostate …
[HTML][HTML] Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement
TRPM8 (melastatine-related transient receptor potential member 8), a member of the
transient receptor potential (TRP) superfamily of cation channels, has been shown to be a …
transient receptor potential (TRP) superfamily of cation channels, has been shown to be a …
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
AI Sagredo, EA Sagredo, V Pola… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+‐activated and voltage‐
dependent monovalent cation channel, which depolarizes the plasma cell membrane …
dependent monovalent cation channel, which depolarizes the plasma cell membrane …
PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
[HTML][HTML] Small molecular inhibitors block TRPM4 currents in prostate cancer cells, with limited impact on cancer hallmark functions
A Borgstroem, B Hauert, S Kappel, E Zoni… - Journal of molecular …, 2021 - Elsevier
Transient receptor potential melastatin 4 (TRPM4) is a broadly expressed Ca 2+ activated
monovalent cation channel that contributes to the pathophysiology of several diseases. For …
monovalent cation channel that contributes to the pathophysiology of several diseases. For …
[HTML][HTML] Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
C Holzmann, S Kappel, T Kilch, MM Jochum… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Impaired Ca 2+ signaling in prostate cancer contributes to several cancer hallmarks, such as
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …
enhanced proliferation and migration and a decreased ability to induce apoptosis. Na+ …
[HTML][HTML] TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells
S Asuthkar, KK Velpula, PA Elustondo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The cold and menthol receptor TRPM8 is highly expressed in prostate and prostate cancer
(PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The …
(PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The …