Systemic inflammation may trigger innate immune memory and persistent changes in
hematopoietic cells through epigenetic mechanisms, though investigating these phenotypes …

Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and
how human infections and associated inflammation can form innate immune memory in …

Severe COVID-19 elicits excessive inflammation mediated by innate immune cells like
monocytes. Recent evidence reveals extensive epigenetic changes in monocytes during …

A new study describes that individuals who recovered from severe coronavirus disease-19
(COVID-19) exhibit long-term epigenetic changes in their hematopoietic stem and progenitor …

In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-
term effects on our immune system leading to, for example, post-acute sequelae of COVID …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

Systemic infection or inflammation can result in long-lasting changes in hematopoiesis by
skewing the differentiation of hematopoietic stem progenitor cells (HSPCs) toward myeloid …

COVID-19 has led to a global pandemic, but the long-term immunological effects of the
infection are only partially understood. A new study now provides important new clues by …

Inflammation activates many blood cell types, driving aging and malignancy. Yet,
hematopoietic stem cells (HSCs) survive a lifetime of infection to sustain life-long blood …

Hematopoietic stem cells (HSC) must persist through a lifetime of infections to ensure life-
long blood production, but whether molecular adaptations following inflammatory stress …