Thinning and discontinuities within the vascular basement membrane (VBM) are associated
with leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in …

Objective: To establish the generality of cerebrovascular pathology frequently observed with
Alzheimer disease, we have assessed blood–brain barrier (BBB) integrity using the …

The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased
parenchymal amyloid plaques. We tested how the APOE genotype correlated with cerebral …

Evidence indicates a critical role for cerebrovascular dysfunction in Alzheimer's disease
(AD) pathophysiology. We have shown that fibrin (ogen), the principal blood-clotting protein …

APOE4 homozygosity has been associated with an increased risk of sporadic Alzheimer's
disease through a mechanism, which has yet to be defined. Recent evidence has suggested …

In vascular dementia (VaD) and Alzheimer's disease (AD), cerebral hypoperfusion and
blood‐brain barrier (BBB) leakiness contribute to brain damage. In this study, we have …

The relative amounts of amyloid β‐protein (Aβ) in cerebral blood vessels and parenchyma
vary considerably amongst patients with Alzheimer's disease (AD). Although several …

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
worldwide. One of the prominent causative factors of AD pathogenesis is cerebral vascular …

Both cerebral amyloid angiopathy and Alzheimer's disease pathology involve abnormal β-
amyloid processing. We aim to elucidate the relationship of the apolipoprotein E (APOE) …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …