Proteins belonging to PD-(D/E) XK phosphodiesterases constitute a functionally diverse
superfamily with representatives involved in replication, restriction, DNA repair and tRNA …

Abstract The PD-(D/E) XK nuclease domains, initially identified in type II restriction enzymes,
serve as models for studying aspects of protein-DNA interactions, mechanisms of …

Abstract Background PD-(D/E) XK nucleases constitute a large and highly diverse
superfamily of enzymes that display little sequence similarity despite retaining a common …

Abstract PD-(D/E) XK nucleases, initially represented by only Type II restriction enzymes,
now comprise a large and extremely diverse superfamily of proteins. They participate in …

Abstract Background The PD-(D/E) XK nuclease superfamily, initially identified in type II
restriction endonucleases and later in many enzymes involved in DNA recombination and …

PDE10A is a cyclic nucleotide phosphodiesterase (PDE) exhibiting properties of a cAMP
PDE and a cAMP‐inhibited cGMP PDE. The transcripts are specifically expressed in the …

PDE11A is a dual‐substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE).
Presently four unique variants carrying distinct GAF sequences in the N‐terminal region …

Background Prediction of structure and function for uncharacterized protein families by
identification of evolutionary links to characterized families and known structures is one of …

Recent progress in the field of cyclic nucleotidos has shown that a large array of closely
related proteins is involved in each step of the signal transduction cascade. Nine families of …

Phosphodiesterase I (EC 3.1. 4.1)/nucleotide pyrophosphatase (EC 3.6. 1.9) enzymes are a
family of type II transmembrane proteins that catalyze the cleavage of phosphodiester and …