Potential Role of APOBEC3 Family Proteins in SARS-CoV-2 Replication

MSTM Begum, A Bokani, SA Rajib, M Soleimanpour… - 2024 - preprints.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired multiple
mutations since its emergence. Analyses of the SARS-CoV-2 genomes from infected …

APOBEC3-related mutations in the spike protein-encoding region facilitate SARS-CoV-2 evolution

J Shen, X Xu, J Fan, H Chen, Y Zhao, W Huang, W Liu… - Heliyon, 2024 - cell.com
SARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces of SARS-
CoV-2 evolution might be activation of apolipoprotein B mRNA editing catalytic subunit-like …

Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome

Y Nakata, H Ode, M Kubota, T Kasahara… - Nucleic Acids …, 2023 - academic.oup.com
The number of genetic variations in the SARS-CoV-2 genome has been increasing primarily
due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine …

The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness

K Kim, P Calabrese, S Wang, C Qin, Y Rao, P Feng… - Scientific Reports, 2022 - nature.com
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …

Regulatory variants of APOBEC3 genes potentially associate with COVID-19 severity in populations with African ancestry

K Zhang, F Chen, HY Shen, PP Zhang, H Gao… - Scientific Reports, 2023 - nature.com
Since November 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused the worldwide pandemic of the coronavirus disease 2019 (COVID-19), the …

The effect of SARS-CoV-2 structural proteins on the expression of cytokines and APOBEC genes in human cell lines

MC Costa - 2023 - repositorio.ul.pt
The global pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) triggered an urgent need to understand the virus's interactions with the human host …

Forty years of HIV research inspires the development of SARS-CoV-2 therapy

R Patarca, WA Haseltine - Journal of Molecular Cell Biology, 2023 - academic.oup.com
Almost four decades ago, the characterization of the human immunodeficiency virus type 1
(HIV-1) genome with the participation of the Haseltine labora-tory at Harvard Medical School …

[PDF][PDF] APOBEC-mediated editing of SARS-CoV-2 genomic RNA impacts viral replication and fitness

K Kim, P Calabrese, S Wang, C Qin… - Preprint at bioRxiv …, 2021 - scienceopen.com
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more virulent and evade vaccines. Viral RNA mutations can arise from misincorporation by …

[HTML][HTML] Host-directed editing of the SARS-CoV-2 genome

T Mourier, M Sadykov, MJ Carr, G Gonzalez… - Biochemical and …, 2021 - Elsevier
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has
facilitated the study of viral genome evolution over a brief period of time. This has …

Rampant C→ U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses: causes and consequences for their short-and long-term evolutionary …

P Simmonds - Msphere, 2020 - Am Soc Microbiol
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
motivated an intensive analysis of its molecular epidemiology following its worldwide …