For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

Individual compartments of abdominal adiposity and lipid content within the liver and muscle
are differentially associated with metabolic risk factors, obesity and insulin resistance …

Fat stored in visceral depots makes obese individuals more prone to complications than
subcutaneous fat. There is good evidence that body fat distribution (FD) is controlled by …

Body fat distribution, particularly centralized obesity, is associated with metabolic risk above
and beyond total adiposity. We performed genome-wide association of abdominal adipose …

Excess body adiposity, especially abdominal obesity and ectopic fat accumulation, are key
risk factors in the development of a number of chronic diseases. The advent of in vivo …

Context: Fat distribution differs in men and women, but in both sexes, a predominantly
gluteal-femoral compared with abdominal (central) fat distribution is associated with lower …

Recent genetic studies have identified alleles associated with opposite effects on adiposity
and risk of type 2 diabetes. We aimed to identify more of these variants and test the …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as
type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat …

For any given body mass index (BMI), individuals vary substantially in fat distribution, and
this variation may have important implications for cardiometabolic risk. Here, we study …