The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

The current testing requirements for both adult and developmental neurotoxicity evaluation
are based on in vivo animal models and the neurotoxic potency of compounds is mainly …

Abstract The Adverse Outcome Pathway (AOP) framework provides a template that
facilitates understanding of complex biological systems and the pathways of toxicity that …

Current risk assessments are mainly based on ecotoxicological endpoints at the level of
individual organisms, but according to the EU directives, the protection goal aims at …

The need for alternative approaches to the use of vertebrate animals for hazard assessment
of chemicals and pollutants has become of increasing importance. It is now the first …

Objective We conducted a review of the history and performance of developmental
neurotoxicity (DNT) testing in support of the finalization and implementation of Organisation …

Chemicals emitted to the environment affect ecosystem health from local to global scale, and
reducing chemical impacts has become an important element of European and global …

New regulations, in particular the new European chemicals legislation (REACH), will
increase the demands on environmental risk assessment (ERA). The requirements on …

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for
Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment …

Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human
exposome. However, DNT data from animal studies are available for only a small …