Kinetochores are the macromolecular complexes that interact with microtubules to mediate chromosome segregation [1]. Accurate segregation requires that kinetochores make …
Y Yamagishi, CH Yang, Y Tanno, Y Watanabe - Nature cell biology, 2012 - nature.com
The genomic stability of all organisms depends on the precise partition of chromosomes to daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores …
Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase …
S Kemmler, M Stach, M Knapp, J Ortiz… - The EMBO …, 2009 - embopress.org
The protein kinase Mps1 is, among others, essential for the spindle assembly checkpoint (SAC). We found that Saccharomyces cerevisiae Mps1 interacts physically with the N …
H Funabiki, DJ Wynne - Chromosoma, 2013 - Springer
The kinetochore, the proteinaceous structure on the mitotic centromere, functions as a mechanical latch that hooks onto microtubules to support directional movement of …
V Vanoosthuyse, KG Hardwick - Current Biology, 2009 - cell.com
The spindle checkpoint is a surveillance system acting in mitosis to delay anaphase onset until all chromosomes are properly attached to the mitotic spindle [1, 2]. When the …
S Vigneron, S Prieto, C Bernis, JC Labbé… - Molecular biology of …, 2004 - Am Soc Cell Biol
The spindle checkpoint prevents anaphase onset until all the chromosomes have successfully attached to the spindle microtubules. The mechanisms by which unattached …
Y Zhao, RH Chen - Current biology, 2006 - cell.com
The spindle checkpoint delays anaphase onset until all chromosomes have achieved bipolar attachment to the spindle microtubules. Unattached kinetochores activate the spindle …
H Yu - Current opinion in cell biology, 2002 - Elsevier
The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase …