Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint

LA Shepperd, JC Meadows, AM Sochaj, TC Lancaster… - Current Biology, 2012 - cell.com
The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that
sister chromatids do not separate until all chromosomes are correctly bioriented during …

Phosphoregulation of Spc105 by Mps1 and PP1 regulates Bub1 localization to kinetochores

N London, S Ceto, JA Ranish, S Biggins - Current Biology, 2012 - cell.com
Kinetochores are the macromolecular complexes that interact with microtubules to mediate
chromosome segregation [1]. Accurate segregation requires that kinetochores make …

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

Y Yamagishi, CH Yang, Y Tanno, Y Watanabe - Nature cell biology, 2012 - nature.com
The genomic stability of all organisms depends on the precise partition of chromosomes to
daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores …

CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

D Hayward, T Alfonso-Pérez, MJ Cundell… - Journal of Cell …, 2019 - rupress.org
Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached
kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase …

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

S Kemmler, M Stach, M Knapp, J Ortiz… - The EMBO …, 2009 - embopress.org
The protein kinase Mps1 is, among others, essential for the spindle assembly checkpoint
(SAC). We found that Saccharomyces cerevisiae Mps1 interacts physically with the N …

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

H Funabiki, DJ Wynne - Chromosoma, 2013 - Springer
The kinetochore, the proteinaceous structure on the mitotic centromere, functions as a
mechanical latch that hooks onto microtubules to support directional movement of …

A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism

V Vanoosthuyse, KG Hardwick - Current Biology, 2009 - cell.com
The spindle checkpoint is a surveillance system acting in mitosis to delay anaphase onset
until all chromosomes are properly attached to the mitotic spindle [1, 2]. When the …

Kinetochore localization of spindle checkpoint proteins: who controls whom?

S Vigneron, S Prieto, C Bernis, JC Labbé… - Molecular biology of …, 2004 - Am Soc Cell Biol
The spindle checkpoint prevents anaphase onset until all the chromosomes have
successfully attached to the spindle microtubules. The mechanisms by which unattached …

[HTML][HTML] Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins

Y Zhao, RH Chen - Current biology, 2006 - cell.com
The spindle checkpoint delays anaphase onset until all chromosomes have achieved
bipolar attachment to the spindle microtubules. Unattached kinetochores activate the spindle …

Regulation of APC–Cdc20 by the spindle checkpoint

H Yu - Current opinion in cell biology, 2002 - Elsevier
The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and
meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase …