SARS-CoV-2-specific T cells exhibit phenotypic features of helper function, lack of terminal differentiation, and high proliferation potential

J Neidleman, X Luo, J Frouard, G Xie, G Gill… - Cell Reports …, 2020 - cell.com
Summary Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …

[HTML][HTML] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19

J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

BJ Meckiff, C Ramírez-Suástegui, V Fajardo, SJ Chee… - Cell, 2020 - cell.com
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

SARS-CoV-2-specific T cells in infection and vaccination

A Bertoletti, N Le Bert, M Qui, AT Tan - Cellular & molecular …, 2021 - nature.com
During viral infections, antibodies and T cells act together to prevent pathogen spread and
remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger …

SARS-CoV-2–specific CD8+ T cell responses in convalescent COVID-19 individuals

H Kared, AD Redd, EM Bloch, TS Bonny… - The Journal of …, 2021 - Am Soc Clin Investig
Characterization of the T cell response in individuals who recover from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical to understanding its …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - Science …, 2020 - science.org
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

Profiling CD8+ T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

H Zhang, S Deng, L Ren, P Zheng, X Hu, T Jin, X Tan - Cell reports, 2021 - cell.com
Cellular immunity is important in determining the disease severity of COVID-19 patients.
However, current understanding of SARS-CoV-2 epitopes mediating cellular immunity is …

Mapping and role of T cell response in SARS-CoV-2–infected mice

Z Zhuang, X Lai, J Sun, Z Chen, Z Zhang… - Journal of Experimental …, 2021 - rupress.org
Virus-specific T cells play essential roles in protection against multiple virus infections,
including SARS-CoV and MERS-CoV. While SARS-CoV-2–specific T cells have been …

[HTML][HTML] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan… - Cell, 2020 - cell.com
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …