Immunomodulatory effects of vitamin D in pregnancy and beyond

F Cyprian, E Lefkou, K Varoudi, G Girardi - Frontiers in immunology, 2019 - frontiersin.org
In addition to its role in calcium homeostasis and bone formation, a modulatory role of the
active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been …

Vitamin D effects on the immune system from periconception through pregnancy

B Schröder-Heurich, CJP Springer… - Nutrients, 2020 - mdpi.com
Vitamin D is a well-known secosteroid and guardian of bone health and calcium
homeostasis. Studies on its role in immunomodulatory functions have expanded its field in …

Vitamin D, autoimmunity and recurrent pregnancy loss: More than an association

K Sharif, Y Sharif, A Watad, Y Yavne… - American Journal of …, 2018 - Wiley Online Library
Recurrent pregnancy loss (RPL) affects close to 1% of couples; however, the etiology is
known in only about 50% of the cases. Recent studies show that autoimmune dysregulation …

Immunological role of vitamin D at the maternal–fetal interface

JA Tamblyn, M Hewison, CL Wagner… - Journal of …, 2015 - joe.bioscientifica.com
During pregnancy, immune activity is tightly regulated so that antimicrobial protection of the
mother and fetus is balanced with the need for immune tolerance to prevent fetal rejection. In …

Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity

K Ota, S Dambaeva, AR Han, K Beaman… - Human …, 2014 - academic.oup.com
Vitamin D, a steroid hormone, is well known to be involved in calciumphosphate
homeostasis and bone metabolism (Halloran et al., 1990; Yoshizawa et al., 1997; Panda et …

Early pregnancy vitamin D status and risk of preeclampsia

H Mirzakhani, AA Litonjua, TF McElrath… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Low vitamin D status in pregnancy was proposed as a risk factor of
preeclampsia. METHODS. We assessed the effect of vitamin D supplementation (4,400 vs …

Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes

SN Karras, CL Wagner, VD Castracane - Metabolism, 2018 - Elsevier
This critical time frame of intrauterine life development is considered of major importance on
the metabolic imprinting of overall health of the offspring, in later life. This requires a delicate …

Impact of vitamin D on pregnancy-related disorders and on offspring outcome

K von Websky, AA Hasan, C Reichetzeder… - The Journal of steroid …, 2018 - Elsevier
Observational studies from all over the world continue to find high prevalence rates of
vitamin D insufficiency and deficiency in many populations, including pregnant women …

Low vitamin D is associated with infections and proinflammatory cytokines during pregnancy

CC Akoh, EK Pressman, E Cooper… - Reproductive …, 2018 - journals.sagepub.com
Vitamin D is known to regulate innate and adaptive immune processes at the cellular level,
but the role of vitamin D status on associated inflammatory processes across pregnancy is …

Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus

CL Wagner, SN Taylor, A Dawodu, DD Johnson… - Nutrients, 2012 - mdpi.com
Despite its discovery a hundred years ago, vitamin D has emerged as one of the most
controversial nutrients and prohormones of the 21st century. Its role in calcium metabolism …