[HTML][HTML] Role of MIF cytokine/CD74 receptor pathway in protecting against injury and promoting repair

L Farr, S Ghosh, S Moonah - Frontiers in immunology, 2020 - frontiersin.org
Wound healing after an injury is essential for life. An in-depth understanding of the healing
process is necessary to ultimately improve the currently limited treatment options for patients …

Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury

S Song, Z Xiao, FJ Dekker, GJ Poelarends… - Cellular and Molecular …, 2022 - Springer
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …

Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair

LM Marsh, L Cakarova… - … of Physiology-Lung …, 2009 - journals.physiology.org
Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine
involved in acute lung injury and other processes such as wound repair and tumor growth …

MIF signal transduction initiated by binding to CD74

L Leng, CN Metz, Y Fang, J Xu, S Donnelly… - The Journal of …, 2003 - rupress.org
Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to
have been described, and it has emerged recently to be an important regulator of innate and …

[PDF][PDF] The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis

R Bucala, I Shachar - Mini Rev Med Chem, 2014 - researchgate.net
Molecules that link innate and adaptive immunity and regulate immune response in health
and disease are now the focus of many studies. This review discusses CD74 and its ligand …

Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury

TA Zimmers, X Jin, EC Hsiao, SA McGrath, AF Esquela… - Shock, 2005 - journals.lww.com
The immunoregulatory cytokine macrophage inhibitory cytokine-1 (MIC-1), a divergent TGF-
β family member, and its murine ortholog, growth/differentiation factor-15 (GDF-15) are …

Evolving complexity of MIF signaling

SS Jankauskas, DWL Wong, R Bucala, S Djudjaj… - Cellular signalling, 2019 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

Y Gore, D Starlets, N Maharshak… - Journal of Biological …, 2008 - ASBMB
Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that
regulates subsequent adaptive responses. It was previously shown that in macrophages …

The macrophage migration inhibitory factor protein superfamily in obesity and wound repair

BS Kim, N Pallua, J Bernhagen, R Bucala - Experimental & molecular …, 2015 - nature.com
The rising number of obese individuals has become a major burden to the healthcare
systems worldwide. Obesity includes not only the increase of adipose tissue mass but …

[PDF][PDF] CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex

X Shi, L Leng, T Wang, W Wang, X Du, J Li… - Immunity, 2006 - cell.com
The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but
the signaling mechanism is not evident. We hypothesized that signaling requires an …