Alzheimer's disease (AD) is an aging-related neurodegenerative disorder. It is characterized
clinically by progressive memory loss and impaired cognitive function. Its progression occurs …

Impairment of energy metabolism is a hallmark of brain aging and several
neurodegenerative diseases, such as the Alzheimer's disease (AD). Age-and disease …

Glial cells are the most abundant cells of the brain, outnumbering neurons. These
multifunctional cells are crucial for maintaining brain homeostasis by providing trophic and …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

The progression and outcome of neurological diseases are determined by the balance
between neurodegeneration, neuroprotection, and neuroregeneration. In this context …

Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Alzheimer's disease (AD) has historically been considered to arise due to the specific
dysfunction and pathology of neurons in brain areas related to cognition. Recent progress …

Neurodegeneration is an age-dependent progressive phenomenon with no defined cause.
Aging is the main risk factor for neurodegenerative diseases. During aging, activated …

Life expectancy in humans is increasing, resulting in a growing aging population, that is
accompanied by an increased disposition to develop cognitive deterioration …

Historically considered as accessory cells to neurons, there is an increasing interest in the
role of astrocytes in normal and pathological conditions. Astrocytes are involved in …