Engineering organoids

M Hofer, MP Lutolf - Nature Reviews Materials, 2021 - nature.com
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Biomaterial-guided stem cell organoid engineering for modeling development and diseases

P Hoang, Z Ma - Acta biomaterialia, 2021 - Elsevier
Organoids are miniature models of organs to recapitulate spatiotemporal cellular
organization and tissue functionality. The production of organoids has revolutionized the …

Engineered organoids for biomedical applications

NR de Barros, C Wang, S Maity, A Peirsman… - Advanced Drug Delivery …, 2023 - Elsevier
As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Middle-out methods for spatiotemporal tissue engineering of organoids

MR Blatchley, KS Anseth - Nature Reviews Bioengineering, 2023 - nature.com
Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …

Organoids-on-a-chip

SE Park, A Georgescu, D Huh - Science, 2019 - science.org
Recent studies have demonstrated an array of stem cell–derived, self-organizing miniature
organs, termed organoids, that replicate the key structural and functional characteristics of …

Bioengineering approaches for the advanced organoid research

SA Yi, Y Zhang, C Rathnam, T Pongkulapa… - Advanced …, 2021 - Wiley Online Library
Recent advances in 3D cell culture technology have enabled scientists to generate stem cell
derived organoids that recapitulate the structural and functional characteristics of native …

Engineering microfluidic organoid-on-a-chip platforms

F Yu, W Hunziker, D Choudhury - Micromachines, 2019 - mdpi.com
In vitro cell culture models are emerging as promising tools to understand human
development, disease progression, and provide reliable, rapid and cost-effective results for …

Tissue geometry drives deterministic organoid patterning

N Gjorevski, M Nikolaev, TE Brown, O Mitrofanova… - Science, 2022 - science.org
INTRODUCTION Stem cell–derived organoids are in vitro tissue and organ mimetics that
have enormous potential as models for human organ development and disease, as …

Next generation organoids for biomedical research and applications

YR Lou, AW Leung - Biotechnology advances, 2018 - Elsevier
Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their
potentials for use in tissue and organ replacement, disease modeling, toxicology studies …

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

N Brandenberg, S Hoehnel, F Kuttler… - Nature biomedical …, 2020 - nature.com
Stem-cell-derived epithelial organoids are routinely used for the biological and biomedical
modelling of tissues. However, the complexity, lack of standardization and quality control of …