We report a multi-ancestry genome-wide association study on liver cirrhosis and its
associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase …

Abstract Background and Aims Cirrhosis is characterized by extensive fibrosis of the liver
and is a major cause of liver‐related mortality. Cirrhosis is partially heritable but genetic …

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …

Alcohol misuse is the leading cause of cirrhosis and the second most common indication for
liver transplantation in the Western world,,. We performed a genome-wide association study …

OBJECTIVES: Variants in patatin-like phospholipase domain-containing 3 (PNPLA3;
rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926), and membrane …

Two genome-wide association studies (GWAS) have described associations of variants in
PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) can progress to cirrhosis and
hepatic decompensation, but whether genetic variants influence the rate of progression to …

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown
etiology that varies in prevalence among ancestry groups. To identify genetic variants …

In a recent issue of the Journal, Atkinson and co-workers reported that a variant in the gene
patatin-like phospholipase domain-containing 3 (PNPLA3) not only affects liver disease …

BACKGROUND & AIMS: Several studies have reported an association between the genetic
variant rs738409 (G) in the PNPLA3 gene and the risk of cirrhosis in various liver diseases …