Introduction Gene identification for genetic diseases is critical for the development of new
diagnostic approaches and personalized treatment options. Prioritization of gene translation …

At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …

Motivation: In attempts to determine the genetic causes of human disease, researchers are
often faced with a large number of candidate genes. Linkage studies can point to a genomic …

Many efforts are still devoted to the discovery of genes involved with specific phenotypes, in
particular, diseases. High‐throughput techniques are thus applied frequently to detect …

Disease-causing aberrations in the normal function of a gene define that gene as a disease
gene. Proving a causal link between a gene and a disease experimentally is expensive and …

Modern high-throughput experiments provide us with numerous potential associations
between genes and diseases. Experimental validation of all the discovered associations, let …

Bioinformatics aids in the understanding of the biological processes of living beings and the
genetic architecture of human diseases. The discovery of disease-related genes improves …

Background Discovering novel disease genes is still challenging for diseases for which no
prior knowledge-such as known disease genes or disease-related pathways-is available …

Candidate gene identification is typically labour intensive, involving laboratory experiments
required to corroborate or disprove any hypothesis for a nominated candidate gene being …

The advance of high-throughput RNA-Sequencing techniques enables researchers to
analyze the complete gene activity in particular cells. From the insights of such analyses …