Abstract LC3-associated phagocytosis (LAP) is a novel form of non-canonical autophagy
where LC3 (microtubule-associated protein 1A/1B–light chain 3) is conjugated to …

Classically, canonical autophagy has been considered a survival mechanism initiated in
response to nutrient insufficiency. We now understand that autophagy functions in multiple …

Autophagy is an intracellular degradative process with a number of roles, one of which can
be the protection of eukaryotic cells from invading microbes. Microtubule-associated protein …

Highlights•LC3-associated phagocytosis (LAP) is a form of non-canonical autophagy that
requires the activity of Rubicon.•Uptake of pathogens, immune complexes, and dying cells …

Highlights•Phagocytes fight pathogens using canonical and noncanonical autophagy
pathways.•PRRs and FcγR trigger LAP, a noncanonical autophagy pathway.•LAP modulates …

The recognition and clearance of dead cells is a process that must occur efficiently to
prevent an autoimmune or inflammatory response. Recently, a process was identified …

Phagocytes ingest, kill and degrade invading microbes in a process called phagocytosis.
LC3-associated phagocytosis (LAP) combines the molecular machinery of phagocytosis …

Highlights•LC3-associated phagocytosis (LAP) and xenophagy target microbes for
lysosomal destruction.•LAP and xenophagy not only make use of shared components but …

A recent report from our group has described that upon engulfment of pathogens, a subset of
phagosomes is formed to preserve antigens for prolonged presentation on MHC class II …

Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …