[HTML][HTML] Synaptic terminal density early in the course of schizophrenia: An in vivo UCB-J positron emission tomographic imaging study of SV2A
Background The synaptic hypothesis is an influential theory of the pathoetiology of
schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the …
schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the …
In vivo evidence of lower synaptic vesicle density in schizophrenia
Decreased synaptic spine density has been the most consistently reported postmortem
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …
[HTML][HTML] Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …
[HTML][HTML] The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET …
EC Onwordi, T Whitehurst, A Mansur, B Statton… - Translational …, 2021 - nature.com
Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia
pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic …
pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic …
Reductions in synaptic marker SV2A in early-course Schizophrenia
Excess synaptic pruning during neurodevelopment has emerged as one of the leading
hypotheses on the causal mechanism for schizophrenia. It proposes that excess synaptic …
hypotheses on the causal mechanism for schizophrenia. It proposes that excess synaptic …
[HTML][HTML] Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Synapse pathology in schizophrenia: a meta-analysis of postsynaptic elements in postmortem brain studies
A Berdenis van Berlekom, CH Muflihah… - Schizophrenia …, 2020 - academic.oup.com
Changed synapse density has been suggested to be involved in the altered brain
connectivity underlying schizophrenia (SCZ) pathology. However, postmortem studies …
connectivity underlying schizophrenia (SCZ) pathology. However, postmortem studies …
Effects of chronic exposure to haloperidol, olanzapine or lithium on SV2A and NLGN synaptic puncta in the rat frontal cortex
Positron emission tomography studies using the synaptic vesicle glycoprotein 2A (SV2A)
radioligand [11 C]-UCB-J provide in vivo evidence for synaptic dysfunction and/or loss in the …
radioligand [11 C]-UCB-J provide in vivo evidence for synaptic dysfunction and/or loss in the …
Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [11C] PBR28 study
Patients with schizophrenia show whole brain and cortical gray matter (GM) volume
reductions which are progressive early in their illness. Microglia, the resident immune cells …
reductions which are progressive early in their illness. Microglia, the resident immune cells …
Neural markers of early remission in first-episode schizophrenia: a volumetric neuroimaging study of the parahippocampus
Using voxel-based morphometry (VBM), our laboratory recently identified significantly lower
grey matter concentration in the parahippocampal gyrus bilaterally in non-remitted patients …
grey matter concentration in the parahippocampal gyrus bilaterally in non-remitted patients …