Empowering SARS‐CoV‐2 variant neutralization with a bifunctional antibody engineered with tandem heptad repeat 2 peptides

JW Kim, JH Lee, HJ Kim, K Heo, Y Lee… - Journal of Medical …, 2024 - Wiley Online Library
With the global pandemic and the continuous mutations of severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), the need for effective and broadly neutralizing …

A potent and protective human neutralizing antibody against SARS-CoV-2 variants

S Shan, CK Mok, S Zhang, J Lan, J Li, Z Yang… - Frontiers in …, 2021 - frontiersin.org
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge and spread around the world, antibodies and vaccines to confer broad and potent …

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

SA Hollingsworth, CL Noland, K Vroom, A Saha… - Scientific Reports, 2023 - nature.com
Coronaviruses have been the causative agent of three epidemics and pandemics in the past
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …

Generation and characterization of humanized synergistic neutralizing antibodies against SARS‐CoV‐2

J Guo, J Zhang, P Du, J Lu, L Chen… - Journal of medical …, 2022 - Wiley Online Library
The emerging coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
2), is the causative agent of coronavirus disease 2019 (COVID‐19), which has become a …

SARS‐CoV‐2 neutralizing antibody epitopes are overlapping and highly mutated which raises the chances of escape variants and requires development of broadly …

J Joseph, S Darpe, G Kulkarni… - … : Structure, Function, and …, 2023 - Wiley Online Library
The rapid adaptation of SARS‐CoV‐2 within the host species and the increased viral
transmission triggered the evolution of different SARS‐CoV‐2 variants. Though numerous …

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike

S De Cae, I Van Molle, L van Schie, SR Shoemaker… - bioRxiv, 2023 - biorxiv.org
Currently circulating SARS-CoV-2 variants have gained complete or significant resistance to
all SARS-CoV-2-neutralizing antibodies that have been used in the clinic. Such antibodies …

Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein

S Xu, Y Wang, Y Wang, C Zhang, Q Hong… - Emerging Microbes & …, 2022 - Taylor & Francis
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern threatens the efficacy of currently approved vaccines and authorized …

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …

Distinct in vitro and in vivo neutralization profiles of monoclonal antibodies elicited by the receptor binding domain of the ancestral SARS‐CoV‐2

HJ Kwon, J Zhang, M Kosikova, W Tang… - Journal of medical …, 2023 - Wiley Online Library
Broadly neutralizing antibodies against severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) variants are sought to curb coronavirus disease 2019 (COVID‐19) …

Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes the omicron variant by disassembling the spike trimer

W Zhan, X Tian, X Zhang, S Xing, W Song… - Journal of …, 2022 - Am Soc Microbiol
The continuous emergence of novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants poses new challenges in the fight against the coronavirus disease …