Retrotransposons mediate gene regulation in important developmental and pathological
processes. Here, we characterized the transient retrotransposon induction during …

Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …

Summary H3K9me3, as a hallmark of heterochromatin, is important for cell-fate specification.
However, it remains unknown how H3K9me3 is reprogrammed during human early embryo …

Here we report that transcriptional effects of the insertion of a retrotransposon can occur
simultaneously both upstream and downstream of the insertion site. We have identified an …

The Cdk8 kinase and associated proteins form a nonessential transcriptional repressor
module of the Mediator in the budding yeast Saccharomyces cerevisiae. Genetic analyses of …

Retrotransposons are highly prevalent in mammalian genomes due to their ability to amplify
in pluripotent cells or developing germ cells. Host mechanisms that silence retrotransposons …

Transposable elements are the largest individual constituent of mammalian genomes.
These elements are highly diverse, a consequence of the multiplicity of genomic habitats …

To better understand transcriptional regulation during human oogenesis and
preimplantation development, we defined stage-specific transcription, which highlighted the …

Abstract Background The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein
1) system plays a central role in repressing transposable elements (TEs) and maintaining …

In higher eukaryotes, reverse transcriptase (RT) activities are encoded by a variety of
endogenous retroviruses and retrotransposable elements. We previously found that mouse …