When stem cells divide, they can generate progeny with the same developmental potential
as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically …

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In the three decades since pluripotent mouse embryonic stem (ES) cells were first described,
they have been derived and maintained by using various empirical combinations of feeder …

The capacity for sustained self-renewal–the generation of daughter cells having the same
regenerative properties as the parent cell–is the defining feature of hematopoietic stem cells …

To what extent are the pathways that regulate self-renewal conserved between stem cells at
different stages of development and in different tissues? Some pathways play a strikingly …

Most current theories assume that self-renewal and differentiation of hematolymphoid stem
cells (HSCs) is randomly regulated by intrinsic and environmental influences. A direct …

Hematopoietic stem cells (HSCs) are generally defined by their dual properties of
pluripotency and extensive self-renewal capacity. However, a lack of experimental clarity as …

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …

The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …