The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice

E Wehrle, A Liedert, A Heilmann… - Disease models & …, 2015 - journals.biologists.com
Fracture healing is impaired in aged and osteoporotic individuals. Because adequate
mechanical stimuli are able to increase bone formation, one therapeutical approach to treat …

Estrogen receptor α-(ERα), but not ERβ-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration

M Haffner-Luntzer, A Kovtun, I Lackner, Y Mödinger… - Bone, 2018 - Elsevier
Mechanostimulation by low-magnitude high frequency vibration (LMHFV) has been shown
to provoke anabolic effects on the intact skeleton in both mice and humans. However …

Estrogen receptor α signaling in osteoblasts is required for mechanotransduction in bone fracture healing

L Steppe, BT Krüger, MEA Tschaffon… - … in Bioengineering and …, 2021 - frontiersin.org
Biomechanical stimulation by whole-body low-magnitude high-frequency vibration (LMHFV)
has demonstrated to provoke anabolic effects on bone metabolism in both non-osteoporotic …

Low-magnitude high-frequency vibration treatment augments fracture healing in ovariectomy-induced osteoporotic bone

HF Shi, WH Cheung, L Qin, AHC Leung, KS Leung - Bone, 2010 - Elsevier
Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration
(LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone. Our …

Distinct frequency dependent effects of whole‐body vibration on non‐fractured bone and fracture healing in mice

E Wehrle, T Wehner, A Heilmann… - Journal of …, 2014 - Wiley Online Library
Low‐magnitude high‐frequency vibration (LMHFV) provokes anabolic effects in non‐
fractured bone; however, in fracture healing, inconsistent results were reported and optimum …

Effects of low-magnitude high-frequency vibration on osteoblasts are dependent on estrogen receptor α signaling and cytoskeletal remodeling

M Haffner-Luntzer, I Lackner, A Liedert… - Biochemical and …, 2018 - Elsevier
Clinical and experimental studies demonstrate the potential of low-magnitude high-
frequency vibration (LMHFV) to enhance bone formation in the intact skeleton and during …

Low‐magnitude high‐frequency vibration enhances gene expression related to callus formation, mineralization and remodeling during osteoporotic fracture healing in …

SL Chung, KS Leung… - Journal of Orthopaedic …, 2014 - Wiley Online Library
Low magnitude high frequency vibration (LMHFV) has been shown to improve anabolic and
osteogenic responses in osteoporotic intact bones and during osteoporotic fracture healing; …

Low‐magnitude high‐frequency vibration (LMHFV) enhances bone remodeling in osteoporotic rat femoral fracture healing

DHK Chow, KS Leung, L Qin… - Journal of …, 2011 - Wiley Online Library
Low‐magnitude high‐frequency vibration (LMHFV)(35 Hz, 0.3 g) accelerates fracture
healing by enhancing callus formation and mineralization for both normal and osteoporotic …

Administration duration influences the effects of low‐magnitude, high‐frequency vibration on ovariectomized rat bone

F Qing, P Xie, YS Liem, Y Chen, X Chen… - Journal of …, 2016 - Wiley Online Library
Low‐magnitude, high‐frequency vibration (LMHFV) has been proposed as a non‐drug anti‐
osteoporosis treatment. However, the influence of administration duration on its effect is …

[PDF][PDF] Vibration treatment modulates macrophage polarisation and enhances early inflammatory response in oestrogen-deficient osteoporotic-fracture healing

SK Chow, YN Chim, J Wang, N Zhang, RM Wong… - Eur Cell …, 2019 - ecmjournal.org
Fracture healing is a well-orchestrated and coordinated process and begins with the
inflammatory stage involving the infiltration of immune cells and the release of cytokines …