MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?
ML Elliott - Ageing research reviews, 2020 - Elsevier
The global population is aging, leading to an increasing burden of age-related
neurodegenerative disease. Efforts to intervene against age-related dementias in older …
neurodegenerative disease. Efforts to intervene against age-related dementias in older …
Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife
AM Racine, RL Koscik, SE Berman, CR Nicholas… - Brain, 2016 - academic.oup.com
The ability to detect preclinical Alzheimer's disease is of great importance, as this stage of
the Alzheimer's continuum is believed to provide a key window for intervention and …
the Alzheimer's continuum is believed to provide a key window for intervention and …
[HTML][HTML] Brain-age is associated with progression to dementia in memory clinic patients
F Biondo, A Jewell, M Pritchard, D Aarsland… - NeuroImage: Clinical, 2022 - Elsevier
Background Biomarkers for the early detection of dementia risk hold promise for better
disease monitoring and targeted interventions. However, most biomarker studies …
disease monitoring and targeted interventions. However, most biomarker studies …
[HTML][HTML] The (limited?) utility of brain age as a biomarker for capturing cognitive decline
A Tetereva, N Pat - eLife, 2023 - elifesciences.org
For decades, neuroscientists have been on a quest to search for a biomarker that can help
capture age-related cognitive decline. One well-known candidate is Brain Age, or a …
capture age-related cognitive decline. One well-known candidate is Brain Age, or a …
[HTML][HTML] BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease
Alzheimer's disease (AD), the most common form of dementia, shares many aspects of
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based …
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based …
[HTML][HTML] Neuroimaging-derived brain-age: an ageing biomarker?
JH Cole - Aging (Albany NY), 2017 - ncbi.nlm.nih.gov
James H. Cole www. aging-us. com AGING 2017, Vol. 9, No. 8 www. aging-us. com 1861
AGING the context of non-pathological ageing, this satisfies criteria# 2. As a non-invasive …
AGING the context of non-pathological ageing, this satisfies criteria# 2. As a non-invasive …
Age-associated differences on structural brain MRI in nondemented individuals from 71 to 103 years
Successful brain aging in the oldest old (≥ 90 years) is underexplored. This study examined
cross-sectional brain morphological differences from 8th to 11th decades of life in …
cross-sectional brain morphological differences from 8th to 11th decades of life in …
Brain-age predicts subsequent dementia in memory clinic patients
INTRODUCTION Research into quantitative neuroimaging biomarkers of dementia risk
rarely uses data representative of everyday clinic practice. METHODS We analysed T1 …
rarely uses data representative of everyday clinic practice. METHODS We analysed T1 …
[HTML][HTML] Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons
Early identification of persons at risk for cognitive decline in aging is critical to optimizing
treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or …
treatment to delay or avoid a clinical diagnosis of mild cognitive impairment (MCI) or …
Brain MRI‐markers Associate Differentially with Cognitive Versus Functional Decline Leading to Dementia
VJA Verlinden, JN van der Geest… - Journal of the …, 2017 - Wiley Online Library
Background Brain MRI‐markers are risk factors of dementia and decline in cognition and
daily functioning. It is unknown to what extent the associations of brain MRI‐markers with …
daily functioning. It is unknown to what extent the associations of brain MRI‐markers with …