Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB (NF-κB) transcription factor
AR Brasier, M Jamaluddin, Y Han, C Patterson… - Molecular and cellular …, 2000 - Springer
The vasopressor octapeptide, angiotensin II (Ang II), exerts homeostatic responses in
cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a …
cardiovascular tissues, including the heart, blood vessel wall, adrenal cortex and liver (a …
Angiotensin II Activates Nuclear Transcription Factor κB Through AT1 and AT2 in Vascular Smooth Muscle Cells: Molecular Mechanisms
M Ruiz-Ortega, O Lorenzo, M Rupérez… - Circulation …, 2000 - Am Heart Assoc
Nuclear factor-κB (NF-κB) regulates many genes involved in vascular physiopathology. We
have previously observed in vivo NF-κB activation in injured vessels that diminished by …
have previously observed in vivo NF-κB activation in injured vessels that diminished by …
Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-κB transcription factors
Y Han, MS Runge, AR Brasier - Circulation research, 1999 - Am Heart Assoc
Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-
stimulated vascular smooth muscle cells (VSMCs) that functions as an autocrine growth …
stimulated vascular smooth muscle cells (VSMCs) that functions as an autocrine growth …
Angiotensin II induces nuclear factor (NF)-κB1 isoforms to bind the angiotensinogen gene acute-phase response element: a stimulus-specific pathway for NF-κB …
M Jamaluddin, T Meng, J Sun, I Boldogh… - Molecular …, 2000 - academic.oup.com
The vasopressor angiotensin II (AII) activates transcriptional expression of its precursor,
angiotensinogen. This biological “positive feedback loop” occurs through an angiotensin …
angiotensinogen. This biological “positive feedback loop” occurs through an angiotensin …
Transcription factor NF-κB is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treated with tumor necrosis factor-α or …
RT Cowling, D Gurantz, JF Peng, WH Dillmann… - Journal of Biological …, 2002 - ASBMB
Tumor necrosis factor-α (TNF-α) and interleukin-1β up-regulate type 1 angiotensin II
receptor (AT 1) mRNA and protein in cultured neonatal rat cardiac fibroblasts. The use of …
receptor (AT 1) mRNA and protein in cultured neonatal rat cardiac fibroblasts. The use of …
Mechanisms for inducible control of angiotensinogen gene transcription
AR Brasier, J Li - Hypertension, 1996 - Am Heart Assoc
The intravascular renin-angiotensin system is an endocrine system designed to maintain
cardiovascular homeostasis in response to hypotension. Under normal conditions …
cardiovascular homeostasis in response to hypotension. Under normal conditions …
Angiotensin II activates nuclear transcription factor‐κB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice
M Ruiz‐Ortega, O Lorenzo, M Rupérez… - Nephrology Dialysis …, 2001 - academic.oup.com
Background. Nuclear factor‐κ B (NF‐κ B) regulates many genes involved in vascular
physiopathology. Angiotensin II (Ang II) participates in the pathogenesis of several …
physiopathology. Angiotensin II (Ang II) participates in the pathogenesis of several …
Dual pathways for nuclear factor κB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IκB kinase and ribosomal kinase
L Zhang, J Cheng, Y Ma, W Thomas, J Zhang, J Du - 2005 - Am Heart Assoc
Activation of nuclear factor (NF)-κB by angiotensin II (Ang II) plays an essential role in
stimulating expression of vascular adhesion molecules, which are essential for vascular …
stimulating expression of vascular adhesion molecules, which are essential for vascular …
Angiotensin IV activates the nuclear transcription factor-κB and related proinflammatory genes in vascular smooth muscle cells
V Esteban, M Ruperez, E Sánchez-López… - Circulation …, 2005 - Am Heart Assoc
Inflammation is a key event in the development of atherosclerosis. Nuclear factor-κB (NF-κB)
is important in the inflammatory response regulation. The effector peptide of the renin …
is important in the inflammatory response regulation. The effector peptide of the renin …
A New Cellular Signaling Mechanism for Angiotensin II Activation of NF-κB: An IκB–Independent, RSK–Mediated Phosphorylation of p65
L Zhang, Y Ma, J Zhang, J Cheng… - … , thrombosis, and vascular …, 2005 - Am Heart Assoc
Objective—Angiotensin II (Ang II) promotes vascular inflammation and remodeling via
activation of nuclear factor κB (NF-κB)–mediated transcription of proinflammatory genes …
activation of nuclear factor κB (NF-κB)–mediated transcription of proinflammatory genes …
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