Cytokine storm (CS), an excessive release of proinflammatory cytokines upon overactivation
of the innate immune system, came recently to the focus of interest because of its role in the …

Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of
complement has recently been emerging. Factor H (FH), the main regulator of the alternative …

The activation of the complement system is a key initiating step in the protective innate
immune-inflammatory response against injury, although it may also cause harm if left …

C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of
complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of …

Factor H (FH) is a major inhibitor of the alternative pathway of complement activation in
plasma and on certain host surfaces. In addition to being a complement regulator, FH can …

Abstract Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue
injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we …

Macrophages are a major immune cell type in the tumor microenvironment, where they
display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also …

Bacterial pathogens not only stimulate innate immune receptors, but also activate the
complement system. Crosstalk between complement C5a receptor (C5aR) and other innate …

Complement is an essential humoral component of innate immunity; however, its
inappropriate activation leads to pathology. Polymorphisms, mutations, and autoantibodies …

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …