Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Regulated cell death (RCD) triggered by innate immune activation is an important strategy
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …

The innate immune system provides the first line of defense against cellular perturbations.
Innate immune activation elicits inflammatory programmed cell death in response to …

Highlights•Innate immune signaling components (RIPK1, TAK1 and ZBP1) are critical
regulators of inflammation and programmed cell death.•Innate signaling connected with …

Programmed cell death (PCD) plays critical roles in development, homeostasis, and both
control and progression of a plethora of diseases, including cancer and neurodegenerative …

Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which
they reside. The activation of these proteins occurs via sequential programs, and much effort …

Historically, cell death and inflammation have been closely linked, but the necessary
divergence of the fields in the past few decades has enriched our molecular understanding …