Transancestral mapping and genetic load in systemic lupus erythematosus

CD Langefeld, HC Ainsworth, DSC Graham… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

Genome‐wide association study in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture

ME Alarcón‐Riquelme, JT Ziegler… - Arthritis & …, 2016 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a
strong genetic component. We undertook the present work to perform the first genome‐wide …

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

YF Wang, Y Zhang, Z Lin, H Zhang, TY Wang… - Nature …, 2021 - nature.com
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

DL Morris, Y Sheng, Y Zhang, YF Wang, Z Zhu… - Nature …, 2016 - nature.com
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

JW Han, HF Zheng, Y Cui, LD Sun, DQ Ye, Z Hu… - Nature …, 2009 - nature.com
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus
(SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using …

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

… for Systemic Lupus Erythematosus Genetics (SLEGEN … - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S=∼ 30). We performed a genome-wide …

[HTML][HTML] Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus

MD Catalina, P Bachali, AE Yeo, NS Geraci, MA Petri… - Jci Insight, 2020 - ncbi.nlm.nih.gov
Gene expression signatures can stratify patients with heterogeneous diseases, such as
systemic lupus erythematosus (SLE), yet understanding the contributions of ancestral …

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap

PS Ramos, LA Criswell, KL Moser, ME Comeau… - PLoS …, 2011 - journals.plos.org
In spite of the well-known clustering of multiple autoimmune disorders in families, analyses
of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) …

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

J Bentham, DL Morris, DS Cunninghame Graham… - Nature …, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease
characterized by loss of immune tolerance to nuclear and cell surface antigens. Previous …

The genetic basis of systemic lupus erythematosus: what are the risk factors and what have we learned

M Teruel, ME Alarcón-Riquelme - Journal of autoimmunity, 2016 - Elsevier
The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …