[HTML][HTML] Macrophages as tools and targets in cancer therapy

A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

[HTML][HTML] Tumor-associated macrophages: recent insights and therapies

J Zhou, Z Tang, S Gao, C Li, Y Feng, X Zhou - Frontiers in oncology, 2020 - frontiersin.org
Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …

[HTML][HTML] Macrophage's role in solid tumors: two edges of a sword

A Jahandideh, M Yarizadeh… - Cancer Cell …, 2023 - Springer
The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …

[HTML][HTML] Understanding the origin and diversity of macrophages to tailor their targeting in solid cancers

K Kielbassa, S Vegna, C Ramirez, L Akkari - Frontiers in immunology, 2019 - frontiersin.org
Tumor-associated macrophages (TAMs) are a major component of the tumor immune
microenvironment (TIME) and are associated with a poor prognostic factor in several …

Macrophages: the road less traveled, changing anticancer therapy

JL Guerriero - Trends in molecular medicine, 2018 - cell.com
Macrophages are present in all vertebrate tissues and have emerged as multifarious cells
with complex roles in development, tissue homeostasis, and disease. Macrophages are a …

[HTML][HTML] Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

[HTML][HTML] Targeting macrophages in cancer: from bench to bedside

AR Poh, M Ernst - Frontiers in oncology, 2018 - frontiersin.org
Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

[PDF][PDF] Macrophages and cancer

A Nardin, JP Abastado - Front Biosci, 2008 - article.imrpress.com
Macrophages are ubiquitous cells physiologically involved in a variety of processes
including pathogen destruction, inflammation, tissue repair and remodeling. They have a …

Macrophages as regulators of tumour immunity and immunotherapy

DG DeNardo, B Ruffell - Nature Reviews Immunology, 2019 - nature.com
Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

[HTML][HTML] Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …