Deciphering the genetic and epigenetic architecture of prostate cancer

SU Nazir, J Mishra, SK Maurya… - … in cancer research, 2024 - pubmed.ncbi.nlm.nih.gov
Prostate cancer, one of the most frequently diagnosed cancers in men, leads to significant
mortality worldwide. Its study is important due to the complexity and diversity in its …

Molecular mechanisms and genetic alterations in prostate cancer: From diagnosis to targeted therapy

F Fontana, M Anselmi, P Limonta - Cancer Letters, 2022 - Elsevier
Prostate cancer remains one of the most lethal malignancies among men worldwide.
Although the primary tumor can be successfully managed by surgery and radiotherapy …

Translational and clinical implications of the genetic landscape of prostate cancer

DE Spratt, ZS Zumsteg, FY Feng… - Nature reviews Clinical …, 2016 - nature.com
Over the past several years, analyses of data from high-throughput studies have elucidated
many fundamental insights into prostate cancer biology. These insights include the …

Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype

D Tong - Critical Reviews in Oncology/Hematology, 2021 - Elsevier
Prostate cancer (PC) is the most frequently diagnosed cancer and the second leading cause
of cancer-related death in men in the Western society. Unfortunately, although the vast …

Expression signature

S Staibano, A Celetti, S Staibano, A Celetti - Prostate Cancer: Shifting from …, 2013 - Springer
The prostate gland can be the site of multiple neoplastic transformation events, many of
which give rise only to latent prostate cancer that does not progress to clinically detectable …

Prostatic adenocarcinoma: molecular underpinnings and treatment-related options

D Paralkar, A Akbari, M Aron - Urologic Oncology: Seminars and Original …, 2024 - Elsevier
Prostate cancer is heterogeneous with varied pathologic features and presents with a wide
spectrum of clinical manifestations from indolent to advanced cancer. Interrogation of the …

Impact of genetic targets on prostate cancer therapy

H Sheikh, J Abdulghani, S Ali, R Sinha… - Impact of Genetic Targets …, 2013 - Springer
Given the global incidence of prostate cancer and its sociological impact, it remains a
challenging disease to clinicians and researchers alike. In the last few years several new …

Molecular heterogeneity in prostate cancer and the role of targeted therapy

S Khan, P Baligar, C Tandon, J Nayyar, S Tandon - Life Sciences, 2023 - Elsevier
Data collected from large-scale studies has shown that the incidence of prostate cancer
globally is on the rise, which could be attributed to an overall increase in lifespan. So, the …

The molecular biology of prostate cancer: current understanding and clinical implications

J Gandhi, A Afridi, S Vatsia, G Joshi, G Joshi… - Prostate cancer and …, 2018 - nature.com
Background With continuous progress over the past few decades in understanding
diagnosis, treatment, and genetics, much has been learned about the prostate cancer …

The genetic complexity of prostate cancer

E Compérat, G Wasinger, A Oszwald, R Kain… - Genes, 2020 - mdpi.com
Prostate cancer (PCa) is a major concern in public health, with many genetically distinct
subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and …